2,5-Dichloro-4-Nitroaniline
A dichlorinated nitroaniline diazo-component intermediate supplied by Chelora Chemicals for azo dye and pigment synthesis — exported from Indonesia in technical and high-purity grades, with full batch documentation on every shipment.
What 2,5-Dichloro-4-Nitroaniline is, and why buyers source it
A working overview of the compound's chemistry, its place in the dichloro-nitroaniline diazo-component family, and the grades Chelora Chemicals keeps in regular supply.
2,5-Dichloro-4-Nitroaniline carries two ring chlorines, at the 2- and 5-positions, together with a nitro group at the 4-position relative to the amino group. With three strongly electron-withdrawing or moderately deactivating substituents on the ring, the amino group here is considerably less nucleophilic than in a mono-substituted chloronitroaniline, and diazotization requires correspondingly forcing acid conditions — conditions the azoic pigment industry uses routinely for exactly this class of diazo component.
At room temperature it is a crystalline solid, light yellow to amber in fresh material, with a tendency to darken toward dark green on prolonged exposure to light and air. It is only sparingly soluble in water, dissolving more readily in polar aprotic solvents such as DMF and DMSO as well as acetone.
Where it fits in the synthesis chain
Like the mono-chloro nitroanilines in our range, this dichlorinated version is used as a diazo component: diazotized under strong acid conditions and coupled with a naphthol AS-type partner to build a specific azoic dye or pigment shade. The additional chlorine shifts the resulting colourant's hue relative to the mono-chloro analogues, which is why formulators specify this exact substitution pattern rather than treating all chloronitroanilines as interchangeable.
Grades we supply
Chelora Chemicals offers 2,5-Dichloro-4-Nitroaniline in technical grade (≈97% assay) for standard industrial dye and pigment manufacture, and high-purity grade (98%+) for applications sensitive to isomer carryover or colour body. Both grades are supplied with a batch-wise certificate of analysis so your incoming QC team can verify the parameters you ordered against.
How 2,5-Dichloro-4-Nitroaniline is made
An overview of the production route for orientation purposes. Our manufacturing partners' own process parameters and in-process controls are proprietary and are not disclosed beyond what is needed to interpret the certificate of analysis.
2,5-Dichloro-4-Nitroaniline is manufactured from 1,4-dichlorobenzene or a related dichlorobenzene precursor by controlled nitration, which installs the nitro group at the position activated by the existing chlorines, followed by selective ammonolysis of one ring chlorine (the one most activated by the adjacent nitro group) to introduce the amino group in its place.
An alternative route starts from 2,5-dichloroaniline and nitrates the ring directly; because the amino group is a strong ortho/para director, the amine is typically protected (commonly by acetylation) before nitration to control regiochemistry and avoid over-oxidation, with the protecting group removed by hydrolysis afterward.
After the key step, the crude product is washed, recrystallized and dried to remove unreacted starting material, regiochemical by-products and process salts before packing. This recrystallization is where technical grade and high-purity grade material part ways.
Why regiochemical control matters here
With two chlorines and a nitro group on the ring, several closely related dichloronitroaniline isomers are possible from the same starting materials. Buyers specifying this product for a dye or pigment batch rely on tight regiochemical control at the nitration and amination steps, since a different dichloronitroaniline isomer carried into the diazotization step would shift the coupled product's shade.
Industries and processes that use it
2,5-Dichloro-4-Nitroaniline is consumed almost entirely as a diazo-component intermediate. The fields below account for most of the global demand we see through our export desk.
Azoic Dyes & Pigments
A diazo component in azoic (naphthol AS) dye and pigment manufacture: diazotized under strong-acid conditions and coupled with a naphthol partner to build the colourant's chromophore.
Pharmaceutical & Fine-Chemical Intermediates
Used as a dichloro-nitroaniline building block in pharmaceutical and fine-chemical synthesis routes that call for this specific substitution pattern.
Specialty Colourant Intermediates
Carried forward into other azoic and pigment chemistries where the 2,5-dichloro, 4-nitro substitution pattern is part of the target structure.
Research & Process Chemistry
Supplied in smaller volumes for process development and analogue synthesis work in agrochemical and pharmaceutical R&D.
How the molecule is typically carried forward
Two chlorines plus a nitro group leave the amino group considerably deactivated, so diazotization needs forcing acid conditions; the ring chlorines themselves are also available for further substitution chemistry.
Diazotization (Diazo Component Use)
Under strong acid conditions suited to heavily deactivated nitroanilines, the amino group is converted to a diazonium salt — the entry point for azoic dye and pigment coupling.
Azo Coupling
The diazonium salt is coupled with a naphthol AS-type coupler to form the azo (–N=N–) chromophore that gives the finished colourant its shade.
Nucleophilic Aromatic Substitution
The ring chlorine activated by the adjacent nitro group can itself be displaced by a nucleophile (amine, alkoxide) under suitable conditions, a route used to access further substituted aniline intermediates.
Nitro Group Reduction
Catalytic or chemical reduction of the nitro group gives the corresponding diaminodichlorobenzene, a route used to access further dye and pharmaceutical intermediates.
2,5-Dichloro-4-Nitroaniline against other chloronitroanilines we supply
Buyers sourcing this dichlorinated diazo component often need a related mono- or dichloro-nitroaniline for a neighbouring shade. A quick reference to what else is on our regular supply list.
| Product | CAS Number | Category | Notes |
|---|---|---|---|
| 2,5-Dichloro-4-Nitroaniline | 6627-34-5 | Dichloro mono-nitro primary arylamine | The product on this page — our most regularly stocked grade of this isomer. |
| 2,6-Dichloro-4-Nitroaniline | 99-30-9 | Dichloro mono-nitro primary arylamine | A positional isomer, also supplied as the Dichloran fungicide active — see its product page. |
| Ortho Chloro Para Nitro Aniline | 121-87-9 | Mono-chloro mono-nitro primary arylamine | A less-substituted diazo component for a different shade target — see its product page. |
| 6-Chloro-2,4-Dinitroaniline | 3531-19-9 | Mono-chloro di-nitro primary arylamine | A more heavily deactivated diazo-component building block — see its product page. |
Exact physical constants and purity specifications are confirmed per batch on the certificate of analysis — treat the notes above as a sourcing guide, not a specification sheet, for products other than 2,5-Dichloro-4-Nitroaniline.
Safety classification at a glance
Based on GHS classification as commonly listed for this substance. This is a summary for orientation only — always work from the current safety data sheet supplied with your specific batch.
Fatal in contact with skin or if inhaled.
Causes skin irritation.
Causes serious eye irritation.
May cause damage to organs through prolonged or repeated exposure.
Toxic to aquatic life, with long-lasting effects.
Treat as a high-hazard material; avoid any skin contact or dust inhalation.
Darkening toward dark green on receipt can indicate degradation; verify against the batch CoA.
Danger — GHS06 toxic, GHS08 health hazard and GHS09 environmental pictograms commonly apply.
Use impervious gloves, full eye/face protection and respiratory protection sized to the task; avoid any skin contact and work under local exhaust ventilation given the severity of this classification. Full first-aid, storage, spill and PPE guidance is in the MSDS issued with every shipment, and should be read in full before this material is handled.
Keeping it on spec between delivery and use
General storage guidance for this grade. Site-specific storage rules, segregation requirements and re-test intervals should follow your own EHS procedures and the MSDS issued with your batch.
Store in a dry, well-ventilated area out of direct sunlight, in tightly closed original packaging, segregated from strong oxidizing and reducing materials. Light and air exposure promote the colour darkening typical of this class of nitroaniline, so keep containers closed between uses. If a batch is held past its retest date, re-check assay and colour before it goes into a process.
How it ships from Indonesia
Standard packing and export terms for this product. Confirm exact figures against your order — they vary slightly by destination and quantity.
What travels with every batch
Specification is agreed before the purchase order, not discovered on arrival. Every shipment of 2,5-Dichloro-4-Nitroaniline leaves with a documented, checkable paper trail.
Certificate of Analysis
Batch-wise assay (by HPLC/GC), melting point range, colour and moisture, issued against the agreed specification so your QC team can check it, not just file it.
Safety Data Sheet
GHS-format SDS in English covering hazard classification, handling, storage, first-aid and spill response for the exact grade shipped.
Technical Data Sheet
Reference physical and chemical properties, recommended storage and typical applications, for internal circulation to your process or R&D teams.
Certificate of Origin
Confirms Indonesian origin for customs clearance and any preferential-duty claim at your destination port.
Dangerous Goods Declaration
UN packing group, classification and shipper's declaration prepared ahead of loading so documentation never holds up customs.
Third-Party Inspection
Independent pre-shipment inspection and re-sampling can be arranged on request, at your cost, for buyers who require it as a matter of policy.
Frequently asked questions
What buyers most often ask our sales desk about this grade.
01What is 2,5-Dichloro-4-Nitroaniline used for?+
02What is the CAS number of 2,5-Dichloro-4-Nitroaniline?+
03What purity grades does Chelora Chemicals supply?+
04Is 2,5-Dichloro-4-Nitroaniline hazardous?+
05How is this different from 2,6-Dichloro-4-Nitroaniline?+
06What packing options are available?+
07How long does delivery take?+
08Can I get a sample before placing a bulk order?+
09Do you supply other chloronitroanilines?+
10How is 2,5-Dichloro-4-Nitroaniline manufactured?+
Need 2,5-Dichloro-4-Nitroaniline on spec, on time?
Send us your required purity, quantity, packing preference and destination port. Our desk quotes most enquiries within one working day.