2-Bromo-4-Fluoro Acetanilide

First, a correction that matters for ordering accuracy: this compound's correct identity is N-(2-bromo-4-fluorophenyl)acetamide, CAS 1009-22-9 — with the bromine positioned ortho and the fluorine positioned para to the acetamido nitrogen. There is a distinct, separately real compound with the positions reversed (N-(4-bromo-2-fluorophenyl)acetamide, CAS 326-66-9, bromine para and fluorine ortho to the nitrogen) that is easy to confuse with this one under loosely written names. We checked the structure (confirmed via its SMILES notation) against the name you gave us and matched it to CAS 1009-22-9 — please verify this is the isomer your process actually requires before ordering, since the two compounds are not interchangeable.

Commercially, this compound combines two useful chemical handles in one molecule: the aryl bromide, which is a standard substrate for Suzuki, Buchwald-Hartwig and related cross-coupling chemistry, and the acetamido-protected aniline nitrogen, which can be deprotected (hydrolysed back to the free amine) for further functionalisation once the coupling chemistry is done. We want to be honest that in the sources we checked, we did not find a specific named pharmaceutical or agrochemical active documented as using this exact intermediate — we describe it here as a generic halogenated building block valued for that two-handle reactivity, not as a precursor to any specific named end product, because that is what the evidence actually supports.

Where it fits in the synthesis chain

We supply this acetanilide intermediate itself, for buyers running their own cross-coupling or deprotection chemistry.

Grades we supply

96–99% grades are seen across the suppliers we benchmarked.

The standard, chemically expected route to this compound is acetylation of 2-bromo-4-fluoroaniline (CAS 656-62-2) with acetic anhydride — a conventional protection step that converts the free, more reactive aniline into the more stable, easier-to-handle acetanilide. Several suppliers list the corresponding free aniline as a related product line, consistent with this being the expected synthesis route.

We want to be honest that we did not locate a process patent explicitly confirming this exact acetylation route for this specific compound in the time available for this research pass — it is the standard, chemically obvious way to make an acetanilide from its corresponding aniline, and commercial naming conventions are consistent with it, but we present it as the expected route rather than an independently verified one.

After acetylation, the crude product is purified by recrystallisation, taking advantage of its well-defined melting point (117–119 °C) to separate it from unreacted aniline starting material and acetic acid/anhydride residues.

A correction worth making explicit: don't confuse the two bromo-fluoro isomers

Because "2-bromo-4-fluoroacetanilide" and "4-bromo-2-fluoroacetanilide" differ only in which position is called "2" and which is called "4" relative to the nitrogen, it is easy for a purchase order or a supplier's own product listing to drift between the two without anyone noticing. They are different, separately real compounds with different CAS numbers. We verify the structure behind every order against its CAS number and SMILES, not just its written name, and recommend buyers do the same when comparing quotes across suppliers.