2,3,4-Trichloro Nitro Benzene
A trichlorinated nitroaromatic intermediate supplied by Chelora Chemicals — the heavily chlorinated starting material for third-generation fluoroquinolone antibacterial synthesis and the Halex route to its trifluoro analogue — exported from Indonesia with full batch documentation on every shipment.
What 2,3,4-Trichloro Nitro Benzene is, and why buyers source it
A working overview of the compound's chemistry, its place as a further-chlorinated relative of our dichloronitrobenzene range, and its documented role in quinolone antibacterial synthesis.
2,3,4-Trichloro Nitro Benzene is a benzene ring carrying three chlorine atoms at the 1, 2 and 3 positions and a nitro group at position 4, making it the most heavily chlorinated member of our chloronitrobenzene range. It can be thought of as a further-chlorinated relative of 3,4-dichloronitrobenzene, carrying an additional chlorine at the position adjacent to the existing pair.
At room temperature it is a white to light yellow crystalline powder. It is practically insoluble in water but dissolves in common organic solvents, and like other nitroaromatics is handled as a material requiring full PPE and MSDS-guided handling rather than a benign commodity solid.
Where it fits in the synthesis chain
This compound is documented as a key starting material for third-generation quinolone antibacterials, feeding the same general synthesis family as lomefloxacin and ofloxacin via a related sequence of ring-functionalisation steps to 3,4-dichloro-1,2-benzenediamine-type intermediates. Its activated ortho-chlorines (flanked by both a nitro group and neighbouring chlorines) also make it a documented substrate for halogen-exchange (Halex) fluorination, converting it to 2,3,4-trifluoronitrobenzene — a route represented elsewhere in our range.
Grades we supply
Chelora Chemicals offers 2,3,4-Trichloro Nitro Benzene in technical grade (≈97% assay) for standard industrial synthesis, and high-purity grade (98%+) for pharmaceutical-intermediate and Halex-feedstock applications sensitive to colour or isomeric carryover. Both grades are supplied with a batch-wise certificate of analysis.
How 2,3,4-Trichloro Nitro Benzene is made
An overview of the production route for orientation purposes. Our manufacturing partners' own process parameters and in-process controls are proprietary and are not disclosed beyond what is needed to interpret the certificate of analysis.
2,3,4-Trichloro Nitro Benzene is manufactured by further chlorinating 3,4-dichloronitrobenzene, or by nitrating 1,2,3-trichlorobenzene, under controlled Lewis-acid-catalysed or mixed-acid conditions depending on the route selected. Industrially, the choice between these two routes generally comes down to feedstock availability and the isomeric purity achievable at each step.
After the halogenation or nitration step, the crude product is separated from residual acid or catalyst, washed, and crystallised to the required purity and colour before packing.
Why this compound matters as a Halex feedstock
Beyond its role in antibacterial synthesis, this trichloronitrobenzene is the standard starting material for the industrial Halex (halogen-exchange) route to 2,3,4-trifluoronitrobenzene: under halogen-exchange conditions with potassium fluoride, a polar aprotic solvent, phase-transfer catalysis and elevated temperature, all three chlorines are sequentially displaced by fluoride, giving the trifluoro product described elsewhere in our range.
Industries and processes that use it
2,3,4-Trichloro Nitro Benzene is consumed mainly as a pharmaceutical synthesis intermediate and as the standard Halex feedstock for its trifluoro analogue. The fields below account for most of the demand we see through our export desk.
Fluoroquinolone Antibacterial Intermediate
A documented starting material feeding the same general synthesis family as lomefloxacin and ofloxacin, via ring-functionalisation to benzenediamine-type intermediates.
Halex Fluorination Feedstock
The standard starting material for the industrial halogen-exchange route to 2,3,4-trifluoronitrobenzene, under potassium fluoride / polar aprotic solvent conditions.
Fine-Chemical & Specialty Synthesis
Used more broadly as a heavily chlorinated nitroaromatic building block in fine-chemical synthesis where multiple ring chlorines are required.
Dye & Pigment Intermediate Chemistry
Its reduction products are used in some dye and pigment intermediate synthesis requiring a trichlorinated aniline building block.
How the molecule is typically carried forward
The nitro group is the reduction handle, while the three chlorines — particularly those flanked by the nitro group and by each other — are activated toward nucleophilic displacement. Reaction classes below cover the main ways this material is converted downstream.
Halex Fluorination
Under halogen-exchange conditions with potassium fluoride, phase-transfer catalysis and elevated temperature, the three chlorines are sequentially displaced by fluoride to give 2,3,4-trifluoronitrobenzene.
Reduction to the Trichloroaniline
Catalytic hydrogenation or chemical reduction converts the nitro group to a primary amine while leaving the chlorines in place, giving a trichloroaniline intermediate used in fluoroquinolone synthesis.
Further Ring Functionalisation
The reduced amine undergoes further nitration/reduction sequences in the established route toward benzenediamine-type intermediates used in quinolone ring-closure chemistry.
Selective Nucleophilic Aromatic Substitution
Individual chlorines, particularly those most strongly activated by the nitro group's position, can be selectively displaced by other nucleophiles under controlled SNAr conditions.
2,3,4-Trichloro Nitro Benzene against other chlorinated and fluorinated nitroaromatics we supply
Buyers sourcing this trichloro intermediate often need either the dichloro precursor or the trifluoro Halex product for a neighbouring step. A quick reference to what else is on our regular supply list.
| Product | CAS Number | Category | Notes |
|---|---|---|---|
| 2,3,4-Trichloro Nitro Benzene | 17700-09-3 | Tri-chloro mono-nitro aromatic | The product on this page — the most heavily chlorinated nitroaromatic in our range. |
| 3,4-Dichloronitrobenzene | 99-54-7 | Di-chloro mono-nitro aromatic | A precursor or lower-chlorinated relative — see its product page. |
| 2,3,4-Trifluoro Nitro Benzene | 771-69-7 | Tri-fluoro mono-nitro aromatic | The Halex fluorination product of this material — see its product page. |
| 2,4,5-Trichloroaniline | 636-30-6 | Tri-chloro aromatic amine | A related trichlorinated aniline elsewhere in our range — see its product page. |
Exact physical constants and purity specifications are confirmed per batch on the certificate of analysis — treat the notes above as a sourcing guide, not a specification sheet, for products other than 2,3,4-Trichloro Nitro Benzene.
Safety classification at a glance
Based on GHS classification as commonly listed for this substance. This is a summary for orientation only — always work from the current safety data sheet supplied with your specific batch.
Harmful if swallowed, in contact with skin or if inhaled.
Causes skin irritation.
Causes serious eye irritation.
May cause respiratory irritation.
Treat as potentially persistent in the environment; avoid any release to drains or waterways.
Impervious gloves, splash-proof eye protection and suitable respiratory protection are the baseline for routine handling.
Crystalline powder can generate dust; local exhaust ventilation is recommended during transfer and weighing.
Warning — GHS07 harmful and irritant pictograms apply.
This compound is harmful by all three common exposure routes and causes skin and eye irritation along with possible respiratory irritation; impervious gloves, splash-proof eye protection and suitable respiratory protection are recommended for routine handling, with attention to dust control during transfer. Full first-aid, storage, spill and PPE guidance is in the MSDS issued with every shipment, and should be read in full before this material is handled.
Keeping it on spec between delivery and use
General storage guidance for this grade. Site-specific storage rules, segregation requirements and re-test intervals should follow your own EHS procedures and the MSDS issued with your batch.
Store in a cool, dry, well-ventilated area away from direct sunlight and ignition sources, in tightly closed original packaging, segregated from strong oxidizing and strong reducing materials. Avoid generating or accumulating dust during handling. If a batch is held past its retest date, re-check assay, melting point and colour before use.
How it ships from Indonesia
Standard packing and export terms for this product. Confirm exact figures against your order — they vary slightly by destination and quantity.
What travels with every batch
Specification is agreed before the purchase order, not discovered on arrival. Every shipment of 2,3,4-Trichloro Nitro Benzene leaves with a documented, checkable paper trail.
Certificate of Analysis
Batch-wise assay, melting point range and colour, issued against the agreed specification so your QC team can check it, not just file it.
Safety Data Sheet
GHS-format SDS in English covering hazard classification, handling, storage, first-aid and spill response for the exact grade shipped.
Technical Data Sheet
Reference physical and chemical properties, recommended storage and typical applications, for internal circulation to your process or R&D teams.
Certificate of Origin
Confirms Indonesian origin for customs clearance and any preferential-duty claim at your destination port.
Dangerous Goods Declaration
UN packing group, classification and shipper's declaration prepared ahead of loading so documentation never holds up customs.
Third-Party Inspection
Independent pre-shipment inspection and re-sampling can be arranged on request, at your cost, for buyers who require it as a matter of policy.
Frequently asked questions
What buyers most often ask our sales desk about this grade.
01What is 2,3,4-Trichloro Nitro Benzene used for?+
02What is the CAS number of 2,3,4-Trichloro Nitro Benzene?+
03How is 2,3,4-Trichloro Nitro Benzene made?+
04What purity grades does Chelora Chemicals supply?+
05Is 2,3,4-Trichloro Nitro Benzene hazardous?+
06How does this relate to 2,3,4-Trifluoro Nitro Benzene?+
07What packing options are available?+
08How long does delivery take?+
09Can I get a sample before placing a bulk order?+
10Do you supply other chlorinated or fluorinated nitroaromatics?+
Need 2,3,4-Trichloro Nitro Benzene on spec, on time?
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