2,6-Dichloro Fluoro Benzene
2,6-Dichloro Fluoro Benzene is a low-melting, crystalline fluorochlorobenzene made commercially by halogen-exchange chemistry, used chiefly as a pharmaceutical and agrochemical building block — with one important physical-state correction up front: this compound is a solid near room temperature, not a liquid, whatever a given supplier datasheet may say.
What 2,6-Dichloro Fluoro Benzene is, and why buyers source it
A working overview of the compound's chemistry, its place in the aniline-derivative family, and the grades Chelora Chemicals keeps in regular supply.
We want to flag a genuine discrepancy in the supplier literature for this exact compound before anything else: at least one commercial datasheet describes it as a liquid, while two independent sources (covering appearance and melting point) describe it as a white-to-light-yellow or orange crystalline solid with a melting point of 37–40 °C. Given that melting point is only modestly above typical warm-climate ambient temperature, we treat this as a solid, low-melting material — and flag the "liquid" description elsewhere in the trade as most likely an error, not a genuine alternate form.
Commercially, this isomer is made by Halex (halogen-exchange) chemistry from a polychlorobenzene precursor, and is used across pharmaceutical, pesticide, dye and liquid-crystal intermediate chemistry. One documented chain ties it to fluoroquinolone antibacterial synthesis (norfloxacin and lomefloxacin are named in supplier literature), though we note this specific attribution rests on a single source and should be read as plausible and consistent with the compound's general chemistry rather than independently verified against a primary patent.
Where it fits in the synthesis chain
We supply the fluorochlorobenzene intermediate itself, not any finished pharmaceutical or agrochemical active built from it.
Grades we supply
98%+ (GC) is the standard commercial grade across suppliers we benchmarked against.
How 2,6-Dichloro Fluoro Benzene is made
An overview of the production route for orientation purposes. Our manufacturing partners' own process parameters and in-process controls are proprietary and are not disclosed beyond what is needed to interpret the certificate of analysis.
2,6-Dichloro Fluoro Benzene is produced industrially by Halex (halogen-exchange) chemistry: a polychlorinated benzene precursor is reacted with a fluoride source (typically potassium fluoride) under conditions that displace one chlorine with fluorine at the activated position, giving this specific chlorofluorobenzene pattern.
This is the standard route documented by at least one major supplier of this compound, and is consistent with how this entire class of chlorofluorobenzenes is made at industrial scale — direct fluorination of benzene itself is not practical, so halogen exchange on a pre-chlorinated ring is the established approach.
The crude product is purified by recrystallisation, taking advantage of its relatively low but well-defined melting point to separate it from residual starting material and other chlorofluorobenzene isomers formed as minor side-products of the halogen-exchange step.
A solid, not a liquid — plan storage and handling accordingly
Because this compound melts only a little above typical warm-climate ambient temperature, it can arrive as either a solid cake or a part-melted mass depending on transit conditions, and that is normal, not a quality defect. We specify it, store it and ship it as the crystalline solid it is, and recommend gently warming and homogenising a shipment before sampling if it has partially melted in transit, rather than treating that as off-spec.
Industries and processes that use it
2,6-Dichloro Fluoro Benzene is consumed almost entirely as a synthesis intermediate. The four fields below account for most of the demand we see through our export desk.
Fluoroquinolone Antibacterial Chemistry
Documented in supplier literature as feeding fluoroquinolone antibacterial synthesis, including norfloxacin and lomefloxacin, via further ring chemistry downstream of this intermediate.
Agrochemical Intermediate Chemistry
Used as a halogenated building block in pesticide synthesis, where the activated fluorochlorobenzene ring supports further substitution.
Dye Intermediate Chemistry
Used in select dye synthesis chains requiring this specific halogenation pattern.
Liquid-Crystal Intermediate Chemistry
Cited by at least one supplier as a building block in liquid-crystal material synthesis, a specialty application distinct from its pharma and agro uses.
How the molecule is typically carried forward
As with the other fluorochlorobenzenes in this range, this molecule's commercial reaction chemistry is about what further substitution or coupling can be built on the existing halogen pattern, rather than reactions at the ring's unsubstituted positions.
Nucleophilic aromatic substitution
The fluorine, activated by the flanking chlorines, is a good leaving group for further nucleophilic substitution chemistry in specialty synthesis — part of why this compound feeds further pharma and agro intermediate chains.
Friedel-Crafts and related electrophilic chemistry
The ring can undergo further electrophilic substitution under appropriate conditions, used in specialty synthesis routes documented by downstream processors rather than performed by us.
Metal-halogen exchange / cross-coupling
The aryl chlorines can participate in metal-catalysed cross-coupling in specialty chemistry, though this is not the standard commercial route for this grade.
2,6-Dichloro Fluoro Benzene against its near relatives
2,6-Dichloro Fluoro Benzene, 2,4-Dichloro Fluoro Benzene and 3,4,5-Trifluoro Bromo Benzene are the three halogenated benzene pharma/agro intermediates in this part of our range.
| Product | CAS Number | Typically Used In | Notes |
|---|---|---|---|
| 2,6-Dichloro Fluoro Benzene | 2268-05-5 | Fluoroquinolone chain (norfloxacin, lomefloxacin) and general pharma/agro intermediate use | The product on this page. Solid, mp 37–40 °C. |
| 2,4-Dichloro Fluoro Benzene | 1435-48-9 | Fluoroquinolone antibacterial chain (ciprofloxacin and related actives) | Also supplied — see its product page. Liquid, mp −23 °C. |
| 3,4,5-Trifluoro Bromo Benzene | 138526-69-9 | General pharmaceutical and agrochemical building block | Also supplied — see its product page. Liquid, mp <−20 °C. |
Exact physical constants and purity specifications are confirmed per batch on the certificate of analysis — treat the notes above as a sourcing guide rather than a specification sheet.
Safety classification at a glance
Based on GHS classification as commonly listed for this substance. This is a summary for orientation only — always work from the current safety data sheet supplied with your specific batch.
Causes skin irritation.
Causes serious eye irritation.
May cause respiratory irritation.
May cause drowsiness or dizziness.
Warning
No harmonised EU CLP Annex VI entry was located for this substance. Two SDS-based sources we checked disagree on part of the classification — one lists a flammable-solid hazard statement (H228) that the other omits, while the other lists a narcotic-effects statement (H336) that the first omits; we present the set most consistent with a crystalline, moderately low-melting solid and recommend checking the SDS shipped with each specific lot. IARC has not evaluated this substance.
Keeping it on spec between delivery and use
General storage guidance for this grade. Site-specific storage rules, segregation requirements and re-test intervals should follow your own EHS procedures and the MSDS issued with your batch.
Store in a cool, dry area below its melting point to keep it as a free-flowing solid; if a shipment arrives part-melted after warm transit, gently homogenise before sampling rather than treating it as off-spec. Keep away from strong oxidisers.
How it ships from Indonesia
Standard packing and export terms for this product. Confirm exact figures against your order — they vary slightly by destination and quantity.
What travels with every batch
Specification is agreed before the purchase order, not discovered on arrival. Every shipment of 2,6-Dichloro Fluoro Benzene leaves with a documented, checkable paper trail.
Certificate of Analysis
Batch-wise assay (by GC), isomer purity, melting point range and moisture, issued against the agreed specification so your QC team can check it, not just file it.
Safety Data Sheet
GHS-format SDS in English covering hazard classification, handling, storage, first-aid and spill response for the exact grade shipped.
Technical Data Sheet
Reference physical and chemical properties, recommended storage and typical applications, for internal circulation to your process or R&D teams.
Certificate of Origin
Confirms Indonesian origin for customs clearance and any preferential-duty claim at your destination port.
Dangerous Goods Declaration
UN packing group, classification and shipper's declaration prepared ahead of loading so documentation never holds up customs.
Third-Party Inspection
Independent pre-shipment inspection and re-sampling can be arranged on request, at your cost, for buyers who require it as a matter of policy.
Frequently asked questions
What buyers most often ask our sales desk about this grade.
01What is 2,6-Dichloro Fluoro Benzene used for?+
02What is the CAS number of 2,6-Dichloro Fluoro Benzene?+
03What purity grades does Chelora Chemicals supply?+
04Is 2,6-Dichloro Fluoro Benzene hazardous?+
05Is this a liquid or a solid?+
06Is this the same compound as 2,4-Dichloro Fluoro Benzene?+
07Why does the hazard classification shown here differ slightly from some other sources?+
08What packing options are available?+
09How long does delivery take?+
10Can I get a sample before placing a bulk order?+
11How is 2,6-Dichloro Fluoro Benzene manufactured?+
12What is the shelf life, and how should it be stored?+
Need 2,6-Dichloro Fluoro Benzene on spec, on time?
Send us your required purity, quantity, packing preference and destination port. Our desk quotes most enquiries within one working day.