3,4,5-Trifluoro Bromo Benzene
3,4,5-Trifluoro Bromo Benzene is a densely halogenated aryl bromide supplied as a pharmaceutical and agrochemical building block, valued chiefly for the aryl-bromide handle it offers to cross-coupling and further substitution chemistry.
What 3,4,5-Trifluoro Bromo Benzene is, and why buyers source it
A working overview of the compound's chemistry, its place in the aniline-derivative family, and the grades Chelora Chemicals keeps in regular supply.
3,4,5-Trifluoro Bromo Benzene carries three fluorines and one bromine on the ring. The bromine is the chemically useful part of this molecule commercially: it is a good leaving group for metal-catalysed cross-coupling chemistry (Suzuki, Negishi and related reactions), while the three fluorines, once installed, are essentially inert spectators that tune the electronics of whatever is built from this starting point. This is the general reason densely fluorinated aryl bromides like this one command a premium over simpler bromobenzenes.
We want to be careful and precise about the specific downstream application here. One promotional secondary source, citing a Chinese patent, names fluxapyroxad — an SDHI (succinate dehydrogenase inhibitor) fungicide — as a documented downstream product reached via this intermediate, through bromination of 2,6-difluoroaniline followed by diazotization-fluorination. We have not independently corroborated that specific attribution against the primary patent text, so we present it as plausible and consistent with this compound's chemistry, not as an independently confirmed fact. More generally and more safely, this compound is documented as a building block for complex pharmaceutical and agrochemical synthesis broadly, without needing to rest on that one specific attribution.
Where it fits in the synthesis chain
We supply the trifluorobromobenzene intermediate itself, not any finished agrochemical or pharmaceutical active built from it.
Grades we supply
95%, 98% and 99% grades are all seen across suppliers we benchmarked; buyers running sensitive cross-coupling chemistry typically specify the higher grades to limit catalyst poisoning from trace impurities.
How 3,4,5-Trifluoro Bromo Benzene is made
An overview of the production route for orientation purposes. Our manufacturing partners' own process parameters and in-process controls are proprietary and are not disclosed beyond what is needed to interpret the certificate of analysis.
Per patent literature cited in trade sources (though not independently verified against the full primary patent text in this research pass), 3,4,5-Trifluoro Bromo Benzene is made from 2,6-difluoroaniline by bromination, followed by diazotization and fluorination of the amino group — a Balz-Schiemann-type sequence using a hydrogen-fluoride amine complex as the fluorinating agent.
This route class — build up the halogenation pattern on an aniline precursor, then convert the amine itself to the final fluorine via diazotization — is standard practice across this entire family of multiply-halogenated benzenes, since direct electrophilic fluorination of an aromatic ring is not a practical industrial reaction.
The crude product is purified by distillation under reduced pressure, which both the low (sub-atmospheric) boiling point data and the compound's sensitivity to prolonged heating at atmospheric pressure make the sensible purification choice over atmospheric distillation.
A note on the fungicide-precursor claim
We'd rather tell you plainly what we could and couldn't verify. A specific downstream link to fluxapyroxad, a commercial SDHI fungicide, appears in trade literature citing a Chinese patent, but we have not independently read and confirmed that patent's full text in researching this page. Treat that specific attribution as plausible rather than independently confirmed, and specify your actual intended end use when ordering so we can flag any screening or documentation requirement relevant to it.
Industries and processes that use it
3,4,5-Trifluoro Bromo Benzene is consumed almost entirely as a synthesis intermediate. The four fields below account for most of the demand we see through our export desk.
Cross-Coupling Chemistry Building Block
The aryl bromide is a standard substrate for Suzuki, Negishi and related metal-catalysed cross-coupling reactions, the main reason this densely fluorinated bromobenzene commands a premium.
Agrochemical Intermediate Chemistry
Documented generally as a building block for complex agrochemical synthesis; one trade source links it, via a cited but not independently verified patent, to SDHI fungicide chemistry.
Pharmaceutical Intermediate Chemistry
Used broadly in pharmaceutical building-block chemistry where a densely fluorinated aryl bromide with this specific substitution pattern is required.
Specialty Fluorochemical Synthesis
Feeds further specialty synthesis wherever the combination of an aryl bromide handle and three ring fluorines is the specific requirement.
How the molecule is typically carried forward
This molecule's commercial reaction chemistry is almost entirely about the bromine: it is the reactive handle for cross-coupling, while the three fluorines are largely inert once installed and serve mainly to tune the electronics of the final product.
Suzuki and related cross-coupling
Palladium-catalysed coupling with a boronic acid or ester replaces the bromine with a new carbon substituent, the standard way this intermediate is advanced in pharmaceutical and agrochemical synthesis.
Negishi and other metal-catalysed coupling
Alternative cross-coupling chemistry (organozinc, organotin partners) can achieve the same bromine-to-carbon substitution where Suzuki conditions aren't suitable.
Lithiation / Grignard formation
The aryl bromide can be converted to an organolithium or Grignard reagent for further carbon-carbon bond formation in specialty synthesis, standard chemistry for an aryl bromide of this type.
3,4,5-Trifluoro Bromo Benzene against its near relatives
3,4,5-Trifluoro Bromo Benzene, 2,4-Dichloro Fluoro Benzene and 2,6-Dichloro Fluoro Benzene are the three halogenated benzene pharma/agro intermediates in this part of our range.
| Product | CAS Number | Typically Used In | Notes |
|---|---|---|---|
| 3,4,5-Trifluoro Bromo Benzene | 138526-69-9 | General pharmaceutical and agrochemical building block; cross-coupling substrate | The product on this page. Liquid, mp <−20 °C. |
| 2,4-Dichloro Fluoro Benzene | 1435-48-9 | Fluoroquinolone antibacterial chain (ciprofloxacin and related actives) | Also supplied — see its product page. Liquid, mp −23 °C. |
| 2,6-Dichloro Fluoro Benzene | 2268-05-5 | Fluoroquinolone chain (norfloxacin, lomefloxacin) and general pharma/agro intermediate use | Also supplied — see its product page. Solid, mp 37–40 °C. |
Exact physical constants and purity specifications are confirmed per batch on the certificate of analysis — treat the notes above as a sourcing guide rather than a specification sheet.
Safety classification at a glance
Based on GHS classification as commonly listed for this substance. This is a summary for orientation only — always work from the current safety data sheet supplied with your specific batch.
Flammable liquid and vapour.
Causes skin irritation.
Causes serious eye damage.
Suspected of causing cancer.
Very toxic to aquatic life with long lasting effects.
Danger
No harmonised EU CLP Annex VI entry was located for this substance — the classification above is self-classification from a single supplier SDS, including a Category 2 carcinogen statement (H351). We want to state plainly that IARC has not evaluated this substance at all; the self-classification and the absence of an IARC review are different kinds of assessment and are not in conflict, but we report both rather than letting the carcinogen statement stand without that context. We recommend checking the SDS shipped with each lot, since this classification rests on a single source we could not independently cross-verify.
Keeping it on spec between delivery and use
General storage guidance for this grade. Site-specific storage rules, segregation requirements and re-test intervals should follow your own EHS procedures and the MSDS issued with your batch.
Store in a cool, well-ventilated area away from ignition sources, given the low flash point. Keep containers tightly sealed to limit evaporative loss, given the compound's low boiling point under reduced pressure.
How it ships from Indonesia
Standard packing and export terms for this product. Confirm exact figures against your order — they vary slightly by destination and quantity.
What travels with every batch
Specification is agreed before the purchase order, not discovered on arrival. Every shipment of 3,4,5-Trifluoro Bromo Benzene leaves with a documented, checkable paper trail.
Certificate of Analysis
Batch-wise assay (by GC), isomer purity, melting point range and moisture, issued against the agreed specification so your QC team can check it, not just file it.
Safety Data Sheet
GHS-format SDS in English covering hazard classification, handling, storage, first-aid and spill response for the exact grade shipped.
Technical Data Sheet
Reference physical and chemical properties, recommended storage and typical applications, for internal circulation to your process or R&D teams.
Certificate of Origin
Confirms Indonesian origin for customs clearance and any preferential-duty claim at your destination port.
Dangerous Goods Declaration
UN packing group, classification and shipper's declaration prepared ahead of loading so documentation never holds up customs.
Third-Party Inspection
Independent pre-shipment inspection and re-sampling can be arranged on request, at your cost, for buyers who require it as a matter of policy.
Frequently asked questions
What buyers most often ask our sales desk about this grade.
01What is 3,4,5-Trifluoro Bromo Benzene used for?+
02What is the CAS number of 3,4,5-Trifluoro Bromo Benzene?+
03What purity grades does Chelora Chemicals supply?+
04Is 3,4,5-Trifluoro Bromo Benzene hazardous?+
05Is the fluxapyroxad link to this compound confirmed?+
06Why does the hazard classification include a carcinogen statement if IARC hasn't evaluated this substance?+
07Why is the boiling point given at reduced pressure rather than at 1 atmosphere?+
08What packing options are available?+
09How long does delivery take?+
10Can I get a sample before placing a bulk order?+
11How is 3,4,5-Trifluoro Bromo Benzene manufactured?+
12What is the shelf life, and how should it be stored?+
Need 3,4,5-Trifluoro Bromo Benzene on spec, on time?
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