2,4-Dichloro Fluoro Benzene
2,4-Dichloro Fluoro Benzene is a halogenated benzene building block whose real commercial identity is as the documented upstream intermediate for the fluoroquinolone family of antibacterials — ciprofloxacin among them — via a well-established acylation chain, not a general-purpose solvent.
What 2,4-Dichloro Fluoro Benzene is, and why buyers source it
A working overview of the compound's chemistry, its place in the aniline-derivative family, and the grades Chelora Chemicals keeps in regular supply.
2,4-Dichloro Fluoro Benzene (2,4-dichloro-1-fluorobenzene) carries two chlorine atoms and one fluorine on the ring in a pattern that is also legitimately written as 1,3-dichloro-4-fluorobenzene — the same molecule, numbered from the opposite direction. Both names appear across supplier literature and refer to the identical compound; we flag this here so a name mismatch on an incoming enquiry or outgoing shipment doesn't read as a different product.
The commercial reason to buy this specific isomer is downstream and well documented: Friedel-Crafts acylation converts it to 2,4-dichloro-5-fluoroacetophenone, the key synthetic intermediate for the fluoroquinolone antibacterial class — ciprofloxacin, enrofloxacin, temafloxacin, and sarafloxacin are all built from that acetophenone. This is a genuine, citable pharmaceutical-intermediate chain, not a general solvent application, and it is the reason purity and isomeric cleanliness on this grade matter more than they would for a commodity chlorobenzene.
Where it fits in the synthesis chain
We supply the fluorobenzene intermediate itself. We do not manufacture or supply the acetophenone intermediate or any finished fluoroquinolone active — buyers working that chain should confirm their own acylation capability or route to a qualified toller.
Grades we supply
96% (GC) is the standard lab-scale grade; 98–99% is offered for buyers running the acylation step directly, where isomeric purity (ortho/para chlorine placement) has a measurable effect on acetophenone yield.
How 2,4-Dichloro Fluoro Benzene is made
An overview of the production route for orientation purposes. Our manufacturing partners' own process parameters and in-process controls are proprietary and are not disclosed beyond what is needed to interpret the certificate of analysis.
Industrial production of 2,4-Dichloro Fluoro Benzene is documented in patent literature as a dedicated process (a US patent specifically titled around its preparation exists), consistent with the general chemistry used across this class of fluorochlorobenzenes: either halogen-exchange (Halex) chemistry on a polychlorinated precursor, or diazotization-fluorination (Balz-Schiemann-type) of a correspondingly substituted dichloroaniline.
We want to be precise about what is and isn't independently verified here: the general route class — Halex or diazotization-fluorination — is the standard, well-established approach for this entire family of fluorochlorobenzenes, and a dedicated patent for this specific compound exists, but we have not independently verified the exact reagents and conditions used industrially beyond that patent's title and general chemistry class.
Whichever route is used, the crude product is purified by fractional distillation to isolate it from the other dichlorofluorobenzene isomers and residual starting material, since boiling points across this isomer family are close enough that distillation column design, not a single simple cut, determines the final isomeric purity.
Why isomeric purity matters more here than on a commodity chlorobenzene
Because this grade's real value is in feeding a specific pharmaceutical acylation step, trace carryover of the 2,6- or other dichlorofluorobenzene isomers isn't just a cosmetic assay issue — it can carry through the Friedel-Crafts acylation and show up as an impurity in the acetophenone intermediate, which pharmaceutical-grade buyers will reject. We verify isomeric purity by GC against reference standards, not by boiling point or density alone.
Industries and processes that use it
2,4-Dichloro Fluoro Benzene is consumed almost entirely as a synthesis intermediate. The four fields below account for most of the demand we see through our export desk.
Fluoroquinolone Antibacterial Chain
Friedel-Crafts acylation gives 2,4-dichloro-5-fluoroacetophenone, the documented key intermediate for ciprofloxacin, enrofloxacin, temafloxacin and sarafloxacin.
Veterinary & Human Antibacterial Synthesis
The same acetophenone chain extends into veterinary fluoroquinolones (enrofloxacin) as well as human antibacterial actives, via established, patent-documented process chemistry.
Nucleophilic Aromatic Substitution Chemistry
The activated ring (chlorine ortho/para to fluorine) supports further substitution chemistry in specialty synthesis beyond the acetophenone route.
General Fine-Chemical Building Block
Used more broadly as a halogenated building block wherever this specific substitution pattern is required in custom or campaign synthesis.
How the molecule is typically carried forward
This molecule's reaction chemistry is almost entirely about what the ring's existing halogens let you build on top of it — principally the Friedel-Crafts acylation that opens the fluoroquinolone chain, though the same activated ring supports other substitution chemistry.
Friedel-Crafts acylation
Reaction with an acylating agent (e.g. acetyl chloride) under Lewis-acid catalysis installs an acetyl group on the ring, giving 2,4-dichloro-5-fluoroacetophenone — the documented entry point to the fluoroquinolone antibacterial chain.
Further nucleophilic aromatic substitution
The fluorine and chlorines, activated by their mutual electron-withdrawing effect, can undergo further substitution with nitrogen or oxygen nucleophiles in specialty synthesis, though this is not the standard commercial route for this grade.
Metal-halogen exchange / cross-coupling
The aryl chlorines can in principle participate in metal-catalysed cross-coupling chemistry, though this is a specialty rather than a standard commercial use for this specific intermediate.
2,4-Dichloro Fluoro Benzene against its near relatives
2,4-Dichloro Fluoro Benzene, 2,6-Dichloro Fluoro Benzene and 3,4,5-Trifluoro Bromo Benzene are the three halogenated benzene pharma/agro intermediates in this part of our range — related by their role as building blocks for further ring chemistry, not by a shared parent structure.
| Product | CAS Number | Typically Used In | Notes |
|---|---|---|---|
| 2,4-Dichloro Fluoro Benzene | 1435-48-9 | Fluoroquinolone antibacterial chain (ciprofloxacin and related actives) | The product on this page. Liquid, mp −23 °C. |
| 2,6-Dichloro Fluoro Benzene | 2268-05-5 | Fluoroquinolone chain (norfloxacin, lomefloxacin) and general pharma/agro intermediate use | Also supplied — see its product page. Solid, mp 37–40 °C. |
| 3,4,5-Trifluoro Bromo Benzene | 138526-69-9 | General pharmaceutical and agrochemical building block | Also supplied — see its product page. Liquid, mp <−20 °C. |
Exact physical constants and purity specifications are confirmed per batch on the certificate of analysis — treat the notes above as a sourcing guide rather than a specification sheet.
Safety classification at a glance
Based on GHS classification as commonly listed for this substance. This is a summary for orientation only — always work from the current safety data sheet supplied with your specific batch.
Flammable liquid and vapour.
Combustible liquid.
Harmful if swallowed.
Causes skin irritation.
May cause damage to organs through prolonged or repeated exposure.
Toxic to aquatic life with long lasting effects.
Warning
No harmonised EU CLP Annex VI entry was located for this substance — the classification above reflects self-classification data (ChemicalBook-sourced), not a binding harmonised entry, and should be checked against the SDS version shipped with your order. IARC has not evaluated this substance. We want to flag plainly that the melting point, density and flash point figures above trace to a single source we could cross-check only partially; treat the specification rail as the governing figure for any given batch, confirmed by its certificate of analysis.
Keeping it on spec between delivery and use
General storage guidance for this grade. Site-specific storage rules, segregation requirements and re-test intervals should follow your own EHS procedures and the MSDS issued with your batch.
Store in a cool, well-ventilated area away from ignition sources and incompatible oxidisers, consistent with a flammable liquid. Keep containers tightly closed to limit moisture pickup, which can affect downstream Friedel-Crafts chemistry.
How it ships from Indonesia
Standard packing and export terms for this product. Confirm exact figures against your order — they vary slightly by destination and quantity.
What travels with every batch
Specification is agreed before the purchase order, not discovered on arrival. Every shipment of 2,4-Dichloro Fluoro Benzene leaves with a documented, checkable paper trail.
Certificate of Analysis
Batch-wise assay (by GC), isomer purity, melting point range and moisture, issued against the agreed specification so your QC team can check it, not just file it.
Safety Data Sheet
GHS-format SDS in English covering hazard classification, handling, storage, first-aid and spill response for the exact grade shipped.
Technical Data Sheet
Reference physical and chemical properties, recommended storage and typical applications, for internal circulation to your process or R&D teams.
Certificate of Origin
Confirms Indonesian origin for customs clearance and any preferential-duty claim at your destination port.
Dangerous Goods Declaration
UN packing group, classification and shipper's declaration prepared ahead of loading so documentation never holds up customs.
Third-Party Inspection
Independent pre-shipment inspection and re-sampling can be arranged on request, at your cost, for buyers who require it as a matter of policy.
Frequently asked questions
What buyers most often ask our sales desk about this grade.
01What is 2,4-Dichloro Fluoro Benzene used for?+
02What is the CAS number of 2,4-Dichloro Fluoro Benzene?+
03What purity grades does Chelora Chemicals supply?+
04Is 2,4-Dichloro Fluoro Benzene hazardous?+
05Do you supply the acetophenone intermediate or finished ciprofloxacin?+
06Is this the same compound as 2,6-Dichloro Fluoro Benzene?+
07Why is the EC number shown with a caveat?+
08What packing options are available?+
09How long does delivery take?+
10Can I get a sample before placing a bulk order?+
11How is 2,4-Dichloro Fluoro Benzene manufactured?+
12What is the shelf life, and how should it be stored?+
Need 2,4-Dichloro Fluoro Benzene on spec, on time?
Send us your required purity, quantity, packing preference and destination port. Our desk quotes most enquiries within one working day.