Skip to content
Vitamin / Nutritional Ingredient · CAS 137-08-6

Calcium Pantothenate (Vitamin B5)

C18H32CaN2O10 Molar mass 476.53 g/mol

The Calcium Pantothenate (Vitamin B5) supplied by Chelora Chemicals — the stable calcium salt form of pantothenic acid used across supplements, food fortification and feed premixes — exported from Indonesia as fine white crystalline powder with full batch documentation on every shipment.

Identification Sheet REP.
IUPAC nameCalcium bis[(R)-pantothenate]
CAS number137-08-6
Molecular formulaC₁₈H₃₂CaN₂O₁₀
Molar mass476.53 g/mol
AppearanceWhite crystalline powder
Common synonymsVitamin B5 (calcium salt), D-Calcium Pantothenate, Calpan
Assay (Purity)≥ 98.0%USP/EP/FCC grade, calculated on dried basis
AppearanceWhite crystalline powderfine, free-flowing, slightly hygroscopic
Solubility in WaterFreely solublecold water
Optical Rotation+25.5° to +27.5°specific rotation, D-form
Loss on Drying≤ 5.0%wt%
Heavy Metals≤ 10 ppmpharmacopoeial/FCC grade
01 / PRODUCT DOSSIER

What Calcium Pantothenate is, and why buyers source it

A working overview of the vitamin's chemistry, why the calcium salt form is used rather than the free acid, and the grades Chelora Chemicals keeps in regular supply.

Calcium Pantothenate is the calcium salt of D-pantothenic acid, vitamin B5, an essential nutrient required by the body to synthesise coenzyme A, a molecule central to fatty-acid metabolism and energy production in every living cell. Pantothenic acid itself is a viscous, highly hygroscopic oil that is impractical to handle, weigh, and formulate at industrial scale; converting it to its calcium salt gives a stable, free-flowing crystalline solid that behaves like an ordinary fine chemical powder, which is the entire reason the calcium salt, rather than the free acid, is the commercial form used throughout the vitamin and supplement industry.

At room temperature it is a white, slightly hygroscopic crystalline powder, freely soluble in water, with only the D-(+)- enantiomer carrying biological vitamin activity — a specification checked by optical rotation on every batch, since the mirror-image L-form, while chemically similar, has no nutritional value and its presence would simply dilute the effective potency of the product.

Where it fits in the value chain

Calcium Pantothenate's largest use is as a vitamin B5 source in human multivitamin and targeted supplement formulations and in food and beverage fortification programmes, where it meets established nutritional reference intakes. A comparably large volume is consumed in animal feed and aquaculture premixes, where vitamin B5 is an essential, feed-mandated nutrient across poultry, swine, and other livestock diets. A smaller volume is used in cosmetic formulation, generally as its related alcohol derivative (panthenol) rather than the calcium salt itself, though calcium pantothenate does appear in some hair and skin-care product lines.

Grades we supply

Chelora Chemicals offers Calcium Pantothenate meeting USP/EP pharmacopoeial and FCC (food-chemical codex) specifications, suited to human supplement, food-fortification and animal-feed-premix use. Each grade is supplied with a batch-wise certificate of analysis covering assay, optical rotation and heavy metals.

02 / MANUFACTURING ROUTE

How Calcium Pantothenate is produced

An overview of the production route for orientation purposes. Our manufacturing partners' own process parameters and in-process controls are proprietary and are not disclosed beyond what is needed to interpret the certificate of analysis.

Calcium Pantothenate is produced synthetically by condensing D-pantolactone (the lactone form of the pantoic-acid portion of the molecule) with beta-alanine under basic conditions, which opens the lactone ring and forms the amide bond that joins the two halves of the finished pantothenic-acid molecule; the resulting pantothenic acid is then neutralised with a calcium source (commonly calcium hydroxide or calcium chloride) to precipitate the stable calcium salt directly from solution.

D-Pantolactone itself is produced by resolving a racemic mixture of pantolactone into its two mirror-image forms, since only the D-form carries vitamin activity, and this resolution step is one of the more demanding parts of the overall route given how similar the two enantiomers are in every property except their biological activity and optical rotation. The crude calcium pantothenate is purified by recrystallisation, with particular attention paid to confirming optical purity, since the finished vitamin's potency is defined entirely by its D-form content.

03 / APPLICATIONS

Industries and processes that use it

Calcium Pantothenate is consumed across human supplementation, food/beverage fortification and animal feed premixes. The fields below account for most of the demand we see through our export desk.

Field 01

Multivitamin & Supplement Formulation

Formulated into multivitamin tablets, capsules and powders as the vitamin B5 source, meeting established nutritional reference intakes.

Field 02

Food & Beverage Fortification

Added directly to food and beverage formulations during processing to meet mandated or voluntary vitamin B5 fortification levels.

Field 03

Animal Feed & Aquaculture Premixes

Included in livestock, poultry and aquaculture vitamin premixes, where vitamin B5 is an essential, feed-mandated nutrient across most commercial diets.

Field 04

Cosmetic & Hair-Care Formulation

Used in some hair and skin-care product formulations, in a market where the related alcohol derivative (panthenol) is more commonly specified.

04 / REACTION CHEMISTRY

How the material is typically formulated forward

The vitamin's water solubility and defined optical purity requirement govern almost all of Calcium Pantothenate's further formulation behaviour. The categories below account for most of the ways it is converted into a finished product.

Multivitamin Tablet/Capsule Formulation

Blended with other vitamins, minerals and excipients and compressed into tablets or filled into capsules as part of a multivitamin or targeted B-complex supplement formulation.

Food/Beverage Fortification

Added directly to food or beverage formulations during processing to meet mandated or voluntary vitamin B5 fortification levels.

Feed Premix Blending

Blended into a concentrated vitamin premix that is then incorporated at a low inclusion rate into complete animal feed or aquaculture formulations.

Cosmetic Formulation Blending

Dissolved into the aqueous phase of certain hair and skin-care formulations, where it is included as a vitamin B5 source.

05 / RELATED BUILDING BLOCKS

Calcium Pantothenate against related vitamin ingredients we supply

Buyers sourcing Calcium Pantothenate for multivitamin or premix formulation often also need the other B-complex and fat-soluble vitamins in the same product. A quick reference to what else is on our regular supply list.

ProductCAS NumberCategoryNotes
Calcium Pantothenate (Vitamin B5)137-08-6Vitamin / nutritional ingredientThe product on this page — the stable calcium salt form of vitamin B5.
Folic Acid59-30-3Vitamin / nutritional ingredientA related B-complex vitamin often formulated into the same multivitamin products — see its product page.
Vitamin E Acetate7695-91-2Fat-soluble vitamin esterA related fat-soluble vitamin from the same nutritional-ingredient range — see its product page.
Niacinamide (Vitamin B3)98-92-0Vitamin / nutritional ingredientA related B-complex vitamin from our pharma & nutritional ingredients range — see its product page.

Exact physical constants and purity specifications are confirmed per batch on the certificate of analysis — treat the notes above as a sourcing guide, not a specification sheet, for products other than Calcium Pantothenate.

06 / HAZARD & HANDLING

Safety classification at a glance

Based on GHS classification as commonly listed for this substance. This is a summary for orientation only — always work from the current safety data sheet supplied with your specific batch.

Low Hazard Profile

Not classified as hazardous under GHS; a recognised, widely used vitamin ingredient.

Combustible Solid

Combustible in dry powder form like most organic solids; store away from open flame.

Dust Control

Minimise airborne dust during milling and packing, as a standard good-practice measure for any fine powder.

Hygroscopicity Note

Slightly hygroscopic; not a safety hazard, but relevant to packaging integrity and quality.

PPE Standard

Standard gloves and good hygiene practice are sufficient for routine handling.

Signal word

Not classified; refer to the batch certificate of analysis and MSDS for full detail.

This product has a low hazard profile and is not classified as hazardous under GHS; it is a recognised, widely used vitamin ingredient handled under standard good-manufacturing-practice precautions rather than chemical-hazard protocols. Its slight hygroscopicity is a quality consideration rather than a safety one, and is managed through appropriate moisture-barrier packaging. Full handling and storage guidance is in the technical data sheet and MSDS issued with every shipment.

07 / STORAGE & SHELF LIFE

Keeping it on spec between delivery and use

General storage guidance for this grade. Site-specific storage rules, segregation requirements and re-test intervals should follow your own EHS procedures and the MSDS issued with your batch.

Storage TemperatureAmbient, dry, indoor
ContainerMoisture-barrier bags / fibre drums
Typical Shelf Life24 months, unopened, moisture-barrier packaging
Keep Away FromMoisture ingress, direct sun, heat
Beyond Shelf LifeRe-check assay and optical rotation before use

Store in a dry, ambient-temperature area in the original moisture-barrier packaging, since the material is slightly hygroscopic and moisture pickup can affect both handling properties and long-term assay. Keep away from direct sunlight and heat sources. Re-check assay and optical rotation on a batch held past its retest date before use.

08 / PACKING & EXPORT

How it ships from Indonesia

Standard packing and export terms for this product. Confirm exact figures against your order — they vary slightly by destination and quantity.

Standard Packing25 kg moisture-barrier bags/drums
Bulk PackingOn request for large volumes
Min. OrderFrom 500 kg
Lead Time2 – 3 weeks
Export TermsFOB · CFR · CIF
09 / QUALITY & DOCUMENTATION

What travels with every batch

Specification is agreed before the purchase order, not discovered on arrival. Every shipment of Calcium Pantothenate (Vitamin B5) leaves with a documented, checkable paper trail.

Doc 01

Certificate of Analysis

Batch-wise assay, colour and key physical constants, issued against the agreed specification so your QC team can check it, not just file it.

Doc 02

Safety Data Sheet

GHS-format SDS in English covering hazard classification, handling, storage, first-aid and spill response for the exact grade shipped.

Doc 03

Technical Data Sheet

Reference physical and chemical properties, recommended storage and typical applications, for internal circulation to your process or R&D teams.

Doc 04

Certificate of Origin

Confirms Indonesian origin for customs clearance and any preferential-duty claim at your destination port.

Doc 05

Dangerous Goods Declaration

UN packing group, classification and shipper's declaration prepared ahead of loading so documentation never holds up customs.

Doc 06

Third-Party Inspection

Independent pre-shipment inspection and re-sampling can be arranged on request, at your cost, for buyers who require it as a matter of policy.

10 / FAQ

Frequently asked questions

What buyers most often ask our sales desk about this grade.

01What is Calcium Pantothenate used for?+
Predominantly as the vitamin B5 source in multivitamin and targeted supplement formulations, food and beverage fortification, and animal feed and aquaculture premixes; also used in some cosmetic and hair-care formulations.
02Why is the calcium salt used instead of pantothenic acid itself?+
Because free pantothenic acid is a viscous, highly hygroscopic oil that is impractical to weigh, handle and formulate at industrial scale, while converting it to its calcium salt gives a stable, free-flowing crystalline powder with the same vitamin activity, which is why the calcium salt, rather than the free acid, is the standard commercial form throughout the vitamin industry.
03How is Calcium Pantothenate produced?+
By condensing D-pantolactone with beta-alanine under basic conditions to form pantothenic acid, then neutralising with a calcium source to precipitate the stable calcium salt directly; D-pantolactone itself is obtained by resolving a racemic mixture into its active D-form.
04What grades does Chelora Chemicals supply?+
We supply USP/EP pharmacopoeial and FCC (food-chemical codex) grades, suited to human supplement, food-fortification and animal-feed-premix use. Each grade ships with a certificate of analysis.
05Is Calcium Pantothenate hazardous?+
No; it has a low hazard profile and is not classified as hazardous under GHS, being a recognised, widely used vitamin ingredient. Standard good-manufacturing-practice handling applies rather than chemical-hazard precautions.
06Why is optical rotation checked on every batch?+
Because only the D-(+)- enantiomer of pantothenic acid carries biological vitamin activity, while the chemically similar mirror-image L-form has no nutritional value, optical rotation is the definitive measure of true vitamin potency, distinct from and more specific than a simple chemical assay, which would not by itself distinguish the active form from an inactive isomer.
07What packing options are available?+
Standard packing is 25 kg moisture-barrier bags or fibre drums, with bulk packing available on request for larger volumes.
08How long does delivery take?+
Typical lead time is two to three weeks plus transit, depending on whether the grade is ex-stock or made to order and your destination port. A firm date is confirmed in the written quotation.
09Can I get a sample before placing a bulk order?+
Yes. Pre-shipment samples and a batch certificate of analysis can be arranged so your QC team can verify the specification before committing to volume.
10Do you supply related vitamin ingredients as well?+
Yes, we also supply Folic Acid and Vitamin E Acetate, two related vitamins from our nutritional-ingredient range, as well as Niacinamide (Vitamin B3).
Request This Grade

Need Calcium Pantothenate on spec, on time?

Send us your required grade (USP/EP/FCC), quantity, packing preference and destination port. Our desk quotes most enquiries within one working day.