2,6-Difluoroaniline
A difluorinated aniline building block supplied by Chelora Chemicals for agrochemical, pharmaceutical and fine-chemical synthesis — exported from Indonesia in technical and high-purity grades, with full batch documentation on every shipment.
What 2,6-Difluoroaniline is, and why buyers source it
A working overview of the compound's chemistry, its place in the fluoroaniline family, and the grades Chelora Chemicals keeps in regular supply.
2,6-Difluoroaniline is a fluorinated derivative of aniline carrying fluorine atoms at both positions flanking the amino group. The symmetrical, ortho,ortho'-difluoro substitution pattern gives the amino group a distinct steric and electronic environment: the two adjacent fluorines withdraw electron density from the ring by induction while still allowing the nitrogen lone pair to participate in reactions typical of primary aromatic amines, including acylation, sulfonylation and diazotization.
At room temperature it is a mobile, colorless to pale yellow liquid rather than a crystalline solid — its melting point sits well below ambient temperature. It is miscible with most common organic solvents (ethanol, acetone, toluene) and only sparingly soluble in water, a solubility profile typical of mono- and di-fluorinated anilines generally.
Where it fits in the synthesis chain
Like other halogenated anilines, 2,6-difluoroaniline is used almost exclusively as a synthesis intermediate rather than as a finished product. The amino group is carried forward into amides, ureas, carbamates or diazonium chemistry to build the active structure of an agrochemical, pharmaceutical or specialty chemical. Because the two ortho-fluorines sit directly next to the reactive nitrogen, buyers specifying this grade are usually building a molecule where that steric and electronic profile is deliberate, which is why isomer purity and residual moisture are checked as closely as the headline assay.
Grades we supply
Chelora Chemicals offers 2,6-Difluoroaniline in technical grade (≈97% assay) for standard industrial synthesis, and high-purity grade (99%+) for applications sensitive to isomer carryover or trace metal content. Both grades are supplied with a batch-wise certificate of analysis so your incoming QC team can verify the parameters you ordered against.
How 2,6-Difluoroaniline is made
An overview of the production route for orientation purposes. Our manufacturing partners' own process parameters and in-process controls are proprietary and are not disclosed beyond what is needed to interpret the certificate of analysis.
Commercial 2,6-difluoroaniline is built up from a chlorinated nitrobenzene precursor through halogen-exchange (Halex) fluorination followed by reduction of the nitro group. 2,6-Dichloronitrobenzene is reacted with a fluoride source — typically potassium fluoride — under elevated temperature in a polar aprotic solvent, with a phase-transfer or crown-ether-type catalyst, to displace both ring chlorines and give 2,6-difluoronitrobenzene.
The resulting dinitro-fluorinated intermediate is then reduced to the amine, most commonly by catalytic hydrogenation (Pd/C or Raney nickel under hydrogen) or, on a smaller scale, by an iron/acid (Béchamp-type) reduction. Hydrogenation conditions are controlled carefully: pressures and temperatures aggressive enough to reduce the nitro group efficiently can also promote partial hydrodehalogenation, stripping a ring fluorine and generating mono-fluoroaniline impurities that purification must then remove.
After reduction, the crude amine is washed and distilled under vacuum to separate unreacted starting material, positional isomers and residual catalyst metals before drying and packing. This distillation cut is where technical grade and high-purity grade material part ways.
Why the halogen-exchange step matters
Because fluorine cannot be introduced onto the ring by direct electrophilic fluorination at commercial scale, essentially all ring-fluorinated anilines reach the market through a Halex step on a chlorinated or nitro-chlorinated precursor. This is also why isomer purity is fixed upstream, at the fluorination stage, rather than corrected afterwards — a point worth keeping in mind when specifying a batch for a process sensitive to isomer carryover.
Industries and processes that use it
2,6-Difluoroaniline is consumed almost entirely as a synthesis intermediate. The fields below account for most of the global demand we see through our export desk.
Crop Protection
A building block for fluorinated herbicide, fungicide and insect-growth-regulator actives, typically carried forward through amide or urea formation.
Pharmaceuticals & Fine Chemicals
Used as a fluorinated aniline core in pharmaceutical and fine-chemical synthesis routes where the ortho,ortho'-difluoro substitution pattern is part of the target molecule.
Dyes & Pigment Intermediates
Diazotized and coupled to build fluorinated chromophore structures for specialty dye and pigment manufacture.
Specialty & Fluorinated Aromatics
A starting material for further fluorinated aromatic intermediates used across process and research chemistry.
How the molecule is typically carried forward
The primary amine is the reactive handle, though the two ortho-fluorines moderate its nucleophilicity. Four reaction classes account for most of the ways 2,6-Difluoroaniline is converted into a finished intermediate downstream.
Acylation
Reaction with an acid chloride or anhydride converts the amine to an amide. This is the most common route for agrochemical and pharmaceutical intermediates built on this scaffold, since the flanking fluorines make the nitrogen a cleaner, more selective acylation handle than an unsubstituted aniline.
Urea & Carbamate Formation
Reaction with an isocyanate or chloroformate builds a urea or carbamate linkage, a common step in constructing herbicide and fungicide active ingredients from fluorinated aniline cores.
Diazotization
Reaction of the amino group with nitrous acid (generated in situ from sodium nitrite and a mineral acid, held below 5 °C) converts the amine into a diazonium salt for azo-coupling or Sandmeyer-type substitution chemistry, though the ortho-fluorines slow this reaction relative to an unhindered aniline.
Sulfonylation
Reaction with a sulfonyl chloride gives a sulfonamide, a linkage used in several agrochemical and pharmaceutical synthesis routes that start from a fluorinated aniline.
2,6-Difluoroaniline against other fluorinated and halogenated anilines we supply
Buyers sourcing 2,6-difluoroaniline often need a related fluorinated or chlorinated aniline building block for a neighbouring step in the same process. A quick reference to what else is on our regular supply list.
| Product | CAS Number | Category | Notes |
|---|---|---|---|
| 2,6-Difluoroaniline | 5509-65-9 | Difluorinated primary arylamine | The product on this page — our most regularly stocked difluoroaniline. |
| 2,3,4-Trifluoroaniline | 3862-73-5 | Trifluorinated primary arylamine | Available to order — see its product page for a full spec. |
| 4-Fluoro-N-Isopropylaniline | 70441-63-3 | Mono-fluorinated secondary arylamine | N-isopropyl substituted; a herbicide-intermediate grade — see its product page. |
| 2,4-Dichloroaniline | 554-00-7 | Dichlorinated primary arylamine | Our chlorinated analogue in the same intermediate class — see its product page. |
Exact physical constants and purity specifications are confirmed per batch on the certificate of analysis — treat the notes above as a sourcing guide, not a specification sheet, for products other than 2,6-Difluoroaniline.
Safety classification at a glance
Based on GHS classification as commonly listed for this substance. This is a summary for orientation only — always work from the current safety data sheet supplied with your specific batch.
Flammable liquid and vapour.
Harmful if swallowed.
Harmful in contact with skin.
Causes skin irritation.
May cause an allergic skin reaction.
Causes serious eye damage.
Harmful if inhaled.
Danger — GHS02 flammable, GHS05 corrosive and GHS07 exclamation-mark pictograms apply.
Handle away from ignition sources with chemical-resistant gloves, eye/face protection and adequate ventilation; avoid breathing vapour or mist. Full first-aid, storage, spill and PPE guidance is in the MSDS issued with every shipment.
Keeping it on spec between delivery and use
General storage guidance for this grade. Site-specific storage rules, segregation requirements and re-test intervals should follow your own EHS procedures and the MSDS issued with your batch.
Store in a dry, well-ventilated area away from direct sunlight and ignition sources, in tightly closed original packaging, segregated from strong oxidizing and acidic materials. Once opened, reseal containers promptly to limit moisture pickup, which affects both the measured assay and handling characteristics. If a batch is held past its retest date, re-check assay and moisture before use.
How it ships from Indonesia
Standard packing and export terms for this product. Confirm exact figures against your order — they vary slightly by destination and quantity.
What travels with every batch
Specification is agreed before the purchase order, not discovered on arrival. Every shipment of 2,6-Difluoroaniline leaves with a documented, checkable paper trail.
Certificate of Analysis
Batch-wise assay (by GC), isomer purity, water content and color, issued against the agreed specification so your QC team can check it, not just file it.
Safety Data Sheet
GHS-format SDS in English covering hazard classification, handling, storage, first-aid and spill response for the exact grade shipped.
Technical Data Sheet
Reference physical and chemical properties, recommended storage and typical applications, for internal circulation to your process or R&D teams.
Certificate of Origin
Confirms Indonesian origin for customs clearance and any preferential-duty claim at your destination port.
Dangerous Goods Declaration
UN packing group, classification and shipper's declaration prepared ahead of loading so documentation never holds up customs.
Third-Party Inspection
Independent pre-shipment inspection and re-sampling can be arranged on request, at your cost, for buyers who require it as a matter of policy.
Frequently asked questions
What buyers most often ask our sales desk about this grade.
01What is 2,6-Difluoroaniline used for?+
02What is the CAS number of 2,6-Difluoroaniline?+
03What purity grades does Chelora Chemicals supply?+
04Is 2,6-Difluoroaniline hazardous?+
05Is 2,6-Difluoroaniline a liquid or a solid?+
06What packing options are available?+
07How long does delivery take?+
08Can I get a sample before placing a bulk order?+
09Do you supply other fluorinated anilines?+
10How is 2,6-Difluoroaniline manufactured?+
Need 2,6-Difluoroaniline on spec, on time?
Send us your required purity, quantity, packing preference and destination port. Our desk quotes most enquiries within one working day.