Para Fluoro Nitro Benzene
A fluorinated nitroaromatic intermediate supplied by Chelora Chemicals, made by the Halex route from Para Nitro Chloro Benzene — valued for a fluorine far more reactive than the equivalent chlorine, and a route into fluoroaniline and nitrodiphenyl-ether chemistry — exported from Indonesia with full batch documentation on every shipment.
What Para Fluoro Nitro Benzene is, and why buyers source it
A working overview of the compound's chemistry, why its fluorine is so much more useful than the chlorine it replaces, and the grades Chelora Chemicals keeps in regular supply.
Para Fluoro Nitro Benzene (4-fluoronitrobenzene) is a benzene ring carrying a fluorine and a nitro group in the 1,4 (para) relationship. Although fluorine is generally a poor leaving group in nucleophilic aromatic substitution for most aryl halides, the opposite is true once the ring carbon is strongly activated by an adjacent or para nitro group: fluoride's high electronegativity makes the carbon-fluorine bond's transition state unusually favourable for the addition step of the SNAr mechanism, so an activated aryl fluoride like this one reacts with nucleophiles considerably faster than the equivalent activated aryl chloride.
With a melting point close to ambient temperature, it is supplied as a pale yellow liquid or a low-melting solid depending on storage temperature. It is only slightly soluble in water but miscible with most organic solvents, and like other nitroaromatics is handled as a toxic material under full MSDS guidance rather than a benign commodity liquid.
Where it fits in the synthesis chain
Catalytic hydrogenation of the nitro group gives 4-fluoroaniline, a precursor to the agricultural fungicide fluoroimide and, further downstream, to pharmaceutical actives such as parafluorofentanyl-class intermediates. The activated fluorine is also displaced directly by phenoxide to give a mononitrodiphenyl ether, a building block used in further diphenyl-ether agrochemical and specialty chemistry.
Grades we supply
Chelora Chemicals offers Para Fluoro Nitro Benzene in technical grade (≈98% assay) for standard industrial synthesis, and high-purity grade (99%+) for applications sensitive to residual chloride or isomeric carryover. Both grades are supplied with a batch-wise certificate of analysis.
How Para Fluoro Nitro Benzene is made
An overview of the production route for orientation purposes. Our manufacturing partners' own process parameters and in-process controls are proprietary and are not disclosed beyond what is needed to interpret the certificate of analysis.
Para Fluoro Nitro Benzene is manufactured by the Halex (halogen-exchange) process: Para Nitro Chloro Benzene is reacted with potassium fluoride, typically in a polar aprotic solvent at elevated temperature, displacing the chlorine with fluoride to give this fluoronitrobenzene and potassium chloride as a by-product. The reaction proceeds because the nitro-activated ring carbon makes the addition-elimination SNAr pathway favourable for fluoride specifically, a reactivity pattern distinctive to activated aryl halides rather than aryl halides in general.
After the halogen-exchange step, the crude product is separated from residual potassium salts and solvent, washed, and distilled to the required purity before packing.
Why the Halex route matters to buyers
Direct nitration of fluorobenzene is not the practical industrial route to this compound; starting from the already-available Para Nitro Chloro Benzene and converting its chlorine to fluorine via Halex is the standard, scalable way to reach this and other activated fluoronitroaromatics, which is why buyers will see the same Halex logic recur across the fluorinated materials in our range.
Industries and processes that use it
Para Fluoro Nitro Benzene is consumed mainly as a feedstock for fluoroaniline chemistry and nitrodiphenyl ether synthesis. The fields below account for most of the demand we see through our export desk.
Fungicide Intermediate (Fluoroimide Route)
Hydrogenation to 4-fluoroaniline feeds the synthesis of the agricultural fungicide fluoroimide.
Pharmaceutical Intermediate Chemistry
4-Fluoroaniline derived from this material is also used further downstream in certain pharmaceutical-intermediate synthesis routes.
Nitrodiphenyl Ether Synthesis
Direct displacement of the activated fluorine by phenoxide gives a mononitrodiphenyl ether building block used in diphenyl-ether agrochemical chemistry.
Fine-Chemical & Specialty Synthesis
Used more broadly as a reactive fluoronitroaromatic building block for SNAr-based fine-chemical synthesis.
How the molecule is typically carried forward
The activated fluorine is an unusually fast-reacting SNAr handle, while the nitro group is the reduction handle for fluoroaniline chemistry. Reaction classes below cover the main ways this material is converted downstream.
Reduction to 4-Fluoroaniline
Catalytic hydrogenation converts the nitro group to a primary amine while the fluorine, generally stable under reducing conditions, is preserved, giving 4-fluoroaniline.
Nucleophilic Aromatic Substitution at Fluorine
The nitro-activated fluorine is displaced by nucleophiles such as phenoxide, alkoxides or amines, often under milder conditions than the equivalent chlorine would require, owing to fluoride's favourable SNAr transition-state energetics once the ring is activated.
Nitrodiphenyl Ether Formation
Reaction with a phenol or phenoxide salt displaces the fluorine to give a mononitrodiphenyl ether, used in further diphenyl-ether agrochemical synthesis.
Further Functionalisation of the Fluoroaniline
4-Fluoroaniline, once formed, can be further acylated or otherwise derivatised in fungicide and pharmaceutical intermediate chemistry.
Para Fluoro Nitro Benzene against other fluorinated and chlorinated nitroaromatics we supply
Buyers sourcing this material often need its difluoro or trifluoro relatives for a different reactivity profile, or the chlorine starting material itself. A quick reference to what else is on our regular supply list.
| Product | CAS Number | Category | Notes |
|---|---|---|---|
| Para Fluoro Nitro Benzene | 350-46-9 | Mono-fluoro mono-nitro aromatic | The product on this page — made by Halex fluorination of Para Nitro Chloro Benzene. |
| Para Nitro Chloro Benzene | 100-00-5 | Mono-chloro mono-nitro aromatic | The Halex starting material for this product — see its product page. |
| 2,4-Difluoro Nitro Benzene | 446-35-5 | Di-fluoro mono-nitro aromatic | A more heavily fluorinated relative — see its product page. |
| 2,3,4-Trifluoro Nitro Benzene | 771-69-7 | Tri-fluoro mono-nitro aromatic | The most heavily fluorinated nitroaromatic in our range — see its product page. |
Exact physical constants and purity specifications are confirmed per batch on the certificate of analysis — treat the notes above as a sourcing guide, not a specification sheet, for products other than Para Fluoro Nitro Benzene.
Safety classification at a glance
Based on GHS classification as commonly listed for this substance. This is a summary for orientation only — always work from the current safety data sheet supplied with your specific batch.
Toxic / harmful if swallowed.
Harmful in contact with skin.
May cause an allergic skin reaction.
Toxic if inhaled.
May cause damage to organs through prolonged or repeated exposure.
Harmful to aquatic life with long-lasting effects.
Impervious gloves, splash-proof eye protection and suitable respiratory protection are the baseline for routine handling.
Danger — GHS06 acute toxicity pictogram applies.
This compound is toxic if swallowed or inhaled, harmful in contact with skin, a skin sensitiser, and may cause organ damage through prolonged or repeated exposure; impervious gloves, full eye/face protection and suitable respiratory protection are the baseline for routine handling, with no skin contact. Full first-aid, storage, spill and PPE guidance is in the MSDS issued with every shipment, and should be read in full before this material is handled.
Keeping it on spec between delivery and use
General storage guidance for this grade. Site-specific storage rules, segregation requirements and re-test intervals should follow your own EHS procedures and the MSDS issued with your batch.
Store in a cool, dry, well-ventilated area away from direct sunlight and ignition sources, in tightly closed original packaging, segregated from strong oxidizing and strong reducing materials. Its melting point sits close to typical ambient temperature, so a container may arrive as a liquid, a solid, or a mix of both; warm gently and mix before sampling if a batch has partially crystallised unevenly. If a batch is held past its retest date, re-check assay and colour before use.
How it ships from Indonesia
Standard packing and export terms for this product. Confirm exact figures against your order — they vary slightly by destination and quantity.
What travels with every batch
Specification is agreed before the purchase order, not discovered on arrival. Every shipment of Para Fluoro Nitro Benzene leaves with a documented, checkable paper trail.
Certificate of Analysis
Batch-wise assay (by GC), residual chloride, colour and water content, issued against the agreed specification so your QC team can check it, not just file it.
Safety Data Sheet
GHS-format SDS in English covering hazard classification, handling, storage, first-aid and spill response for the exact grade shipped.
Technical Data Sheet
Reference physical and chemical properties, recommended storage and typical applications, for internal circulation to your process or R&D teams.
Certificate of Origin
Confirms Indonesian origin for customs clearance and any preferential-duty claim at your destination port.
Dangerous Goods Declaration
UN packing group, classification and shipper's declaration prepared ahead of loading so documentation never holds up customs.
Third-Party Inspection
Independent pre-shipment inspection and re-sampling can be arranged on request, at your cost, for buyers who require it as a matter of policy.
Frequently asked questions
What buyers most often ask our sales desk about this grade.
01What is Para Fluoro Nitro Benzene used for?+
02What is the CAS number of Para Fluoro Nitro Benzene?+
03How is Para Fluoro Nitro Benzene made?+
04What purity grades does Chelora Chemicals supply?+
05Is Para Fluoro Nitro Benzene hazardous?+
06Why does fluorine react faster than chlorine here?+
07What packing options are available?+
08How long does delivery take?+
09Can I get a sample before placing a bulk order?+
10Do you supply other fluoronitroaromatic building blocks?+
Need Para Fluoro Nitro Benzene on spec, on time?
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