2,4-Difluoro Nitro Benzene
A difluorinated nitroaromatic intermediate supplied by Chelora Chemicals, carrying two independently nitro-activated fluorines for sequential or selective nucleophilic substitution — a documented building block in antimicrobial and fine-chemical synthesis — exported from Indonesia with full batch documentation on every shipment.
What 2,4-Difluoro Nitro Benzene is, and why buyers source it
A working overview of the compound's chemistry, how its two fluorines sit at different activation levels, and the grades Chelora Chemicals keeps in regular supply.
2,4-Difluoro Nitro Benzene is a benzene ring carrying fluorine atoms at positions 2 and 4 and a nitro group at position 1, meaning each fluorine is activated toward nucleophilic aromatic substitution by the nitro group — one ortho, the other para — but to different degrees and with different steric environments. This makes selective, sequential functionalisation possible: one fluorine can often be displaced preferentially over the other under carefully chosen conditions, a feature synthetic chemists specifically exploit when building more complex fluoroaromatic targets.
At room temperature it is a clear, light yellow to brown liquid, since its melting point sits below typical ambient conditions. It is only slightly soluble in water but miscible with most organic solvents, and like other nitroaromatics is handled as a toxic material under full MSDS guidance rather than a benign commodity liquid.
Where it fits in the synthesis chain
This compound is a documented precursor in the sulfonation route to 2,4-difluoro-5-nitrobenzenesulfonic acid, and has been used in the synthesis of (±)-horsfiline (an oxindole alkaloid target in methodology research) and of resin-bound 2-arylaminobenzimidazoles. It also serves as a reactant in preparing 4-thiazolidinone derivatives investigated as antimicrobial agents, reflecting its broader role as a versatile difluoronitroaromatic building block in fine-chemical and pharmaceutical-intermediate research.
Grades we supply
Chelora Chemicals offers 2,4-Difluoro Nitro Benzene in technical grade (≈98% assay) for standard industrial synthesis, and high-purity grade (99%+) for research and pharmaceutical-intermediate applications sensitive to colour or isomeric carryover. Both grades are supplied with a batch-wise certificate of analysis.
How 2,4-Difluoro Nitro Benzene is made
An overview of the production route for orientation purposes. Our manufacturing partners' own process parameters and in-process controls are proprietary and are not disclosed beyond what is needed to interpret the certificate of analysis.
2,4-Difluoro Nitro Benzene is manufactured by the Halex (halogen-exchange) process from the corresponding dichloronitrobenzene precursor, reacting it with potassium fluoride under elevated temperature in a polar aprotic solvent to displace both chlorines sequentially with fluoride. As with the mono-fluoro analogue elsewhere in our range, the nitro group's activation is what makes this halogen-exchange route practical at scale.
After the halogen-exchange step, the crude product is separated from residual potassium salts and solvent, washed, and distilled to the required purity before packing.
Why two fluorines, not two chlorines
Buyers sometimes ask why a process would call for both ring halogens as fluorine rather than chlorine: the answer is almost always because the subsequent synthesis step itself needs the faster, more controllable SNAr kinetics that an activated aryl fluoride offers over the equivalent aryl chloride, as described on our Para Fluoro Nitro Benzene page.
Industries and processes that use it
2,4-Difluoro Nitro Benzene is consumed mainly in fine-chemical and pharmaceutical-intermediate research, exploiting its two differently activated fluorines for selective, sequential functionalisation. The fields below cover the uses we see most often through our export desk.
4-Thiazolidinone Antimicrobial Intermediate Chemistry
A documented reactant in preparing 4-thiazolidinone derivatives investigated as antimicrobial agents.
Alkaloid & Heterocycle Methodology Research
Used in the synthesis of (±)-horsfiline, an oxindole alkaloid target, and of resin-bound 2-arylaminobenzimidazoles in methodology research.
Sulfonation Intermediate Chemistry
A documented precursor in the sulfonation route to 2,4-difluoro-5-nitrobenzenesulfonic acid.
Fine-Chemical & Specialty Synthesis
Supplied more broadly as a versatile difluoronitroaromatic building block for sequential SNAr-based fine-chemical synthesis.
How the molecule is typically carried forward
The two nitro-activated fluorines, ortho and para to the nitro group respectively, offer sequential or selective SNAr chemistry, while the nitro group itself remains available for reduction. Reaction classes below cover the main ways this material is converted downstream.
Selective Displacement of the Para Fluorine
The fluorine para to the nitro group is typically the more reactive of the two under kinetically controlled conditions, and can often be displaced selectively by a first nucleophile.
Displacement of the Remaining Ortho Fluorine
Under a separate step with a different nucleophile and typically more forcing conditions, the remaining ortho fluorine can then be displaced, allowing two different substituents to be installed sequentially.
Sulfonation
Reaction under sulfonating conditions gives 2,4-difluoro-5-nitrobenzenesulfonic acid, an intermediate used in further specialty synthesis.
Reduction of the Nitro Group
Catalytic hydrogenation converts the nitro group to a primary amine, generally preserving both fluorines, to give a difluoroaniline building block for further downstream chemistry.
2,4-Difluoro Nitro Benzene against other fluorinated nitroaromatics we supply
Buyers sourcing this difluoro intermediate often need the mono-fluoro or trifluoro relatives for a different reactivity profile. A quick reference to what else is on our regular supply list.
| Product | CAS Number | Category | Notes |
|---|---|---|---|
| 2,4-Difluoro Nitro Benzene | 446-35-5 | Di-fluoro mono-nitro aromatic | The product on this page — two differently activated fluorines on the same ring. |
| Para Fluoro Nitro Benzene | 350-46-9 | Mono-fluoro mono-nitro aromatic | The simpler mono-fluoro relative — see its product page. |
| 2,3,4-Trifluoro Nitro Benzene | 771-69-7 | Tri-fluoro mono-nitro aromatic | A more heavily fluorinated relative — see its product page. |
| 2,4-Dinitro Fluoro Benzene | 70-34-8 | Fluoro-dinitro aromatic | The dinitro, mono-fluoro analogue (Sanger's reagent) — see its product page. |
Exact physical constants and purity specifications are confirmed per batch on the certificate of analysis — treat the notes above as a sourcing guide, not a specification sheet, for products other than 2,4-Difluoro Nitro Benzene.
Safety classification at a glance
Based on GHS classification as commonly listed for this substance. This is a summary for orientation only — always work from the current safety data sheet supplied with your specific batch.
Toxic if swallowed.
Causes skin irritation.
Causes serious eye irritation.
May cause respiratory irritation.
Impervious gloves, splash-proof eye protection and suitable respiratory protection are the baseline for routine handling.
Being a liquid at ambient temperature, splash exposure during transfer is a particular handling risk; use closed-system transfer where practical.
Avoid any release to drains or waterways as a general nitroaromatic precaution.
Danger — GHS06 acute toxicity pictogram applies.
This compound is toxic if swallowed and causes skin and eye irritation along with possible respiratory irritation; impervious gloves, full eye/face protection and suitable respiratory protection are the baseline for routine handling. Because it is a liquid at typical ambient temperature, splash exposure during transfer and sampling is a particular risk, so closed-system transfer is recommended where practical. Full first-aid, storage, spill and PPE guidance is in the MSDS issued with every shipment, and should be read in full before this material is handled.
Keeping it on spec between delivery and use
General storage guidance for this grade. Site-specific storage rules, segregation requirements and re-test intervals should follow your own EHS procedures and the MSDS issued with your batch.
Store in a cool, dry, well-ventilated area away from direct sunlight and ignition sources, in tightly closed original packaging, segregated from strong oxidizing and strong reducing materials. As a low-melting liquid at ambient temperature, ensure containers are well sealed to prevent vapour loss and contamination. If a batch is held past its retest date, re-check assay and colour before use.
How it ships from Indonesia
Standard packing and export terms for this product. Confirm exact figures against your order — they vary slightly by destination and quantity.
What travels with every batch
Specification is agreed before the purchase order, not discovered on arrival. Every shipment of 2,4-Difluoro Nitro Benzene leaves with a documented, checkable paper trail.
Certificate of Analysis
Batch-wise assay (by GC), colour and water content, issued against the agreed specification so your QC team can check it, not just file it.
Safety Data Sheet
GHS-format SDS in English covering hazard classification, handling, storage, first-aid and spill response for the exact grade shipped.
Technical Data Sheet
Reference physical and chemical properties, recommended storage and typical applications, for internal circulation to your process or R&D teams.
Certificate of Origin
Confirms Indonesian origin for customs clearance and any preferential-duty claim at your destination port.
Dangerous Goods Declaration
UN packing group, classification and shipper's declaration prepared ahead of loading so documentation never holds up customs.
Third-Party Inspection
Independent pre-shipment inspection and re-sampling can be arranged on request, at your cost, for buyers who require it as a matter of policy.
Frequently asked questions
What buyers most often ask our sales desk about this grade.
01What is 2,4-Difluoro Nitro Benzene used for?+
02What is the CAS number of 2,4-Difluoro Nitro Benzene?+
03How is 2,4-Difluoro Nitro Benzene made?+
04What purity grades does Chelora Chemicals supply?+
05Is 2,4-Difluoro Nitro Benzene hazardous?+
06Why does this molecule have two differently reactive fluorines?+
07What packing options are available?+
08How long does delivery take?+
09Can I get a sample before placing a bulk order?+
10Do you supply other fluoronitroaromatic building blocks?+
Need 2,4-Difluoro Nitro Benzene on spec, on time?
Send us your required purity, quantity, packing preference and destination port. Our desk quotes most enquiries within one working day.