Para Anisidine
Para Anisidine is the positional isomer of Ortho Anisidine, and we want to state a correction plainly up front: a carcinogenicity (H350) statement for this compound circulates on some general-reference sources, but it is contradicted by the pharmacology/toxicology literature (INCHEM), ACGIH, and German MAK data we checked, and we do not publish it. The hazard this compound's data actually and consistently supports is haematological -- methaemoglobin formation -- the same mechanism that makes aniline itself a recognised blood hazard.
What Para Anisidine is, and why buyers source it
A working overview of the compound's chemistry, its place in the aniline-derivative family, and the grades Chelora Chemicals keeps in regular supply.
Para Anisidine places its methoxy group para to the amino group, giving a solid (unlike the liquid ortho isomer) with distinct hazard data. We checked a Wikipedia-sourced H350 ("may cause cancer") claim against INCHEM's toxicological review, ACGIH's documentation, and German MAK Commission data, and found the carcinogenicity claim is not supported by the weight of that evidence -- we do not publish it on this page. What is consistently documented instead is this compound's capacity to cause methaemoglobinaemia (a blood disorder reducing oxygen-carrying capacity), the same toxicological mechanism documented for aniline and several of its simpler derivatives, and that is the hazard driver we foreground here.
Commercially, Para Anisidine is documented as a coupling component and intermediate in azoic/Naphthol AS dye chemistry and in antioxidant synthesis, built on the same diazotisable amino group as its ortho isomer, with the methoxy group's para position giving it a distinct coupling behaviour and colour range from the ortho isomer.
Where it fits in the synthesis chain
We supply Para Anisidine itself as a dye and fine-chemical intermediate. We do not manufacture or supply the finished dyes or antioxidant products made from it.
Grades we supply
99%+ is the standard commercial grade.
How Para Anisidine is made
An overview of the production route for orientation purposes. Our manufacturing partners' own process parameters and in-process controls are proprietary and are not disclosed beyond what is needed to interpret the certificate of analysis.
Para Anisidine is made industrially by reduction of para-nitroanisole, itself made by methylation of para-nitrophenol or by nitration of anisole followed by isomer separation from the ortho isomer.
The nitro-to-amine reduction step uses catalytic hydrogenation or a chemical reducing agent, converting the nitro group to the amine while leaving the methoxy group and ring untouched.
The crude product is purified by crystallisation, taking advantage of its solid state at ambient temperature (unlike the liquid ortho isomer), then dried and tested for purity and colour before packing.
A carcinogenicity claim we checked and did not publish
We take this kind of correction seriously, because getting it wrong in either direction has real consequences. A carcinogen (H350) classification for this compound appears on some general-reference sources. We cross-checked it against INCHEM's toxicological review, ACGIH documentation, and German MAK Commission data, and found that weight of evidence does not support publishing an H350 statement for this compound. We instead report, consistently across the sources we checked, its documented capacity to cause methaemoglobinaemia -- a real and well-supported hazard, distinct from and not to be confused with carcinogenicity.
Industries and processes that use it
Para Anisidine is consumed almost entirely as a synthesis intermediate. The four fields below account for most of the demand we see through our export desk.
Azoic Dye Coupler
Documented as a coupling component in azoic/Naphthol AS dye chemistry, built on its diazotisable amino group.
Antioxidant & Fine-Chemical Intermediate
Used as an intermediate in antioxidant synthesis and more broadly in fine-chemical synthesis requiring this specific methoxy/amino substitution pattern.
How the molecule is typically carried forward
Para Anisidine's chemistry centres on the amino group's diazotisation, the key activating step for its documented azoic-dye coupling applications.
Diazotisation
The amino group is converted to a diazonium salt with nitrous acid, the key activating step for azoic-dye coupling chemistry.
Azo coupling
The diazonium salt couples with a naphthol or similar coupling partner, with the para-substitution pattern giving a distinct colour range from the ortho isomer.
Para Anisidine against its near relatives
Para Anisidine and Ortho Anisidine are the two anisidine isomers in this part of our range, differing meaningfully in both physical state and hazard profile.
| Product | CAS Number | Typically Used In | Notes |
|---|---|---|---|
| Para Anisidine | 104-94-9 | Azoic dye coupler/antioxidant intermediate | The product on this page. Not classified as a carcinogen; haematological hazard (methaemoglobinaemia). |
| Ortho Anisidine | 90-04-0 | Azo-dye and pigment intermediate | Also supplied -- see its product page. EU Carc. 1B (H350); IARC Group 2B. |
Exact physical constants and purity specifications are confirmed per batch on the certificate of analysis — treat the notes above as a sourcing guide rather than a specification sheet.
Safety classification at a glance
Based on GHS classification as commonly listed for this substance. This is a summary for orientation only — always work from the current safety data sheet supplied with your specific batch.
Harmful if swallowed.
Harmful in contact with skin.
Harmful if inhaled.
May cause damage to organs (blood) through prolonged or repeated exposure.
Very toxic to aquatic life with long lasting effects.
Warning
No harmonised EU CLP Annex VI carcinogen entry was located for this substance, and we deliberately do not publish a carcinogenicity (H350) statement that circulates on some general-reference sources, having checked it against INCHEM's toxicological review, ACGIH documentation, and German MAK Commission data and found it unsupported by the weight of that evidence. The classification above instead reflects the consistently documented haematological hazard mechanism (H373, blood/methaemoglobinaemia) shared with aniline and related simple anilines, alongside general acute-toxicity statements. IARC has not evaluated this substance.
Keeping it on spec between delivery and use
General storage guidance for this grade. Site-specific storage rules, segregation requirements and re-test intervals should follow your own EHS procedures and the MSDS issued with your batch.
Store in a cool, dark, well-ventilated area away from strong oxidisers, consistent with a documented blood-toxicity profile and its tendency to darken on exposure to air and light. PPE including skin and respiratory protection is recommended for all handling.
How it ships from Indonesia
Standard packing and export terms for this product. Confirm exact figures against your order — they vary slightly by destination and quantity.
What travels with every batch
Specification is agreed before the purchase order, not discovered on arrival. Every shipment of Para Anisidine leaves with a documented, checkable paper trail.
Certificate of Analysis
Batch-wise assay (by GC), isomer purity, melting point range and moisture, issued against the agreed specification so your QC team can check it, not just file it.
Safety Data Sheet
GHS-format SDS in English covering hazard classification, handling, storage, first-aid and spill response for the exact grade shipped.
Technical Data Sheet
Reference physical and chemical properties, recommended storage and typical applications, for internal circulation to your process or R&D teams.
Certificate of Origin
Confirms Indonesian origin for customs clearance and any preferential-duty claim at your destination port.
Dangerous Goods Declaration
UN packing group, classification and shipper's declaration prepared ahead of loading so documentation never holds up customs.
Third-Party Inspection
Independent pre-shipment inspection and re-sampling can be arranged on request, at your cost, for buyers who require it as a matter of policy.
Frequently asked questions
What buyers most often ask our sales desk about this grade.
01What is Para Anisidine used for?+
02What is the CAS number of Para Anisidine?+
03What purity grades does Chelora Chemicals supply?+
04Is Para Anisidine hazardous?+
05Is this compound a carcinogen?+
06Is this the same as Ortho Anisidine?+
07What packing options are available?+
08How long does delivery take?+
09Can I get a sample before placing a bulk order?+
10How is Para Anisidine manufactured?+
11What is the shelf life, and how should it be stored?+
Need Para Anisidine on spec, on time?
Send us your required purity, quantity, packing preference and destination port. Our desk quotes most enquiries within one working day.