2-Amino-4-Nitrophenol
The 2-Amino-4-Nitrophenol supplied by Chelora Chemicals — a tri-substituted aromatic intermediate central to oxidative hair-colour chemistry and select pharmaceutical synthesis — exported from Indonesia as fine crystalline powder with full batch documentation on every shipment.
What 2-Amino-4-Nitrophenol is, and why buyers source it
A working overview of the compound's tri-substituted ring chemistry, its central role in oxidative hair-colour formulation, and the grades Chelora Chemicals keeps in regular supply.
2-Amino-4-Nitrophenol combines three functional groups — a hydroxyl, an amine and a nitro group — arranged around the same benzene ring, and the particular combination and positioning of these groups is what gives the compound its characteristic yellow-to-brownish colour and its reactivity as a coupler in oxidative colouring systems. It is one of a family of small nitro-aminophenol and aminophenol compounds developed specifically for the hair-colour industry, where its own colour contributes directly to the shade produced, in addition to reacting with other dye-system components during the oxidative colour-development process.
At room temperature it is a yellow to brownish-yellow crystalline powder, only slightly soluble in cold water but considerably more soluble in dilute acid or alkaline solution, which is how it is typically dissolved and incorporated into the cream or liquid base of a hair-colour formulation.
Where it fits in the value chain
The great majority of 2-Amino-4-Nitrophenol demand comes from the oxidative hair-colouring industry, where it is formulated as a direct (non-oxidative-coupling) colouring component in semi-permanent and, combined with other couplers and oxidation bases, permanent hair-colour systems, contributing orange-red to red-brown shades. A smaller volume is used as an intermediate in the synthesis of other dyes and pharmaceutical fine chemicals, where its combination of amine, hydroxyl and nitro reactivity is useful for building more complex substituted-aromatic target molecules.
Grades we supply
Chelora Chemicals offers 2-Amino-4-Nitrophenol in cosmetic-intermediate grade, meeting the purity and heavy-metal limits expected of hair-colour formulation raw materials, and in technical grade for other dye and chemical-intermediate applications. Each grade is supplied with a batch-wise certificate of analysis.
How 2-Amino-4-Nitrophenol is produced
An overview of the production route for orientation purposes. Our manufacturing partners' own process parameters and in-process controls are proprietary and are not disclosed beyond what is needed to interpret the certificate of analysis.
2-Amino-4-Nitrophenol is produced predominantly by the selective partial reduction of 2,4-dinitrophenol, converting one of the two nitro groups to an amine while leaving the other intact; achieving this selectivity — reducing only one nitro group rather than both, and the correct one rather than its isomer — is the key process challenge, typically managed with a controlled catalytic hydrogenation or a selective chemical reducing system under carefully limited conditions.
An alternative route starts from m-aminophenol (3-aminophenol) and introduces the nitro group by controlled nitration at the position that gives the desired 2-amino-4-nitro substitution pattern, though the selective reduction of 2,4-dinitrophenol is generally the more direct and widely used commercial route. Either way, the crude product is purified by recrystallisation to reach the colour, assay and heavy-metal specification required of cosmetic-intermediate grade.
Industries and processes that use it
2-Amino-4-Nitrophenol is consumed predominantly by the oxidative hair-colouring industry, with a smaller volume into dye and pharma intermediate chemistry. The fields below account for most of the demand we see through our export desk.
Oxidative Hair-Colour Formulation
Formulated as a direct colouring component in semi-permanent and permanent hair-colour systems, contributing orange-red to red-brown shades alongside other couplers and oxidation bases.
Dye Intermediate Synthesis
Used as a building block in the synthesis of other azo and specialty dyes, exploiting its amine group's diazotisation reactivity.
Pharmaceutical Fine-Chemical Intermediate
Used in the synthesis of select pharmaceutical fine chemicals where the specific amine/hydroxyl/nitro substitution pattern is a useful synthetic starting point.
Analytical & Laboratory Reagent Use
Supplied in smaller quantities as a laboratory reagent and reference standard for analytical and research applications.
How the molecule is typically carried forward
The combined amine, hydroxyl and nitro reactivity governs almost all of 2-Amino-4-Nitrophenol's further reaction chemistry. The categories below account for most of the ways it is converted into a finished product.
Hair-Colour Formulation Blending
Dissolved into the cream or liquid base of an oxidative hair-colour formulation alongside oxidation bases, other couplers and an alkalising agent, where it contributes its own colour and interacts during oxidative colour development.
Diazotisation
The amine group is converted to a diazonium salt under acidic nitrous acid conditions, a step toward further azo dye synthesis via subsequent coupling reactions.
Further Nitro-Group Reduction
The remaining nitro group can itself be reduced in a subsequent step to give a diaminophenol, a useful intermediate for other substituted-aromatic target molecules.
Etherification/Esterification of the Phenol
The phenolic hydroxyl can be alkylated or esterified to mask its reactivity while retaining the amine and nitro groups for further synthetic steps.
2-Amino-4-Nitrophenol against a related aminophenol we supply
Buyers sourcing 2-Amino-4-Nitrophenol sometimes also need the simpler, unsubstituted aminophenol for a different pharma or dye intermediate route. A quick reference to what else is on our regular supply list.
| Product | CAS Number | Category | Notes |
|---|---|---|---|
| 2-Amino-4-Nitrophenol | 99-57-0 | Substituted aminophenol | The product on this page — a key coupler in oxidative hair-colour chemistry. |
| 4-Aminophenol | 123-30-8 | Aromatic aminophenol | A related, simpler aminophenol best known as the precursor to paracetamol API — see its product page. |
| Diphenylamine | 122-39-4 | Aromatic amine | A related aromatic amine intermediate from our aromatic amine range — see its product page. |
| Hydroxylamine Sulfate | 10039-54-0 | Inorganic amine reagent | A related nitrogen-chemistry reagent used elsewhere in fine-chemical and nylon intermediate synthesis — see its product page. |
Exact physical constants and purity specifications are confirmed per batch on the certificate of analysis — treat the notes above as a sourcing guide, not a specification sheet, for products other than 2-Amino-4-Nitrophenol.
Safety classification at a glance
Based on GHS classification as commonly listed for this substance. This is a summary for orientation only — always work from the current safety data sheet supplied with your specific batch.
Harmful if swallowed.
May cause an allergic skin reaction.
Causes serious eye irritation.
Toxic to aquatic life with long-lasting effects.
Chemical-resistant gloves, safety glasses and a dust mask are the baseline for routine handling.
As with many hair-colour-chemistry intermediates, skin sensitisation potential should be assessed per the intended formulation and regulatory regime.
Warning
This product is harmful if swallowed and may cause an allergic skin reaction and eye irritation on contact, and is toxic to aquatic life with long-lasting effects, so release to drains and watercourses should be avoided. Routine handling calls for chemical-resistant gloves, eye protection and a dust mask given its fine powder form. Formulators should additionally confirm the compound's acceptance and permitted concentration under the cosmetic regulations of their target market, since hair-colour ingredient lists are subject to regional restriction. Full first-aid, storage, spill and PPE guidance is in the MSDS issued with every shipment, and should be read in full before this material is handled.
Keeping it on spec between delivery and use
General storage guidance for this grade. Site-specific storage rules, segregation requirements and re-test intervals should follow your own EHS procedures and the MSDS issued with your batch.
Store in a cool, dark, dry area in tightly closed containers, since light exposure can affect colour consistency over time, a property directly relevant to its use as a hair-colour shade component. Keep away from strong oxidising agents. Re-check assay and colour on a batch held past its retest date before use, particularly before committing it to cosmetic-grade formulation.
How it ships from Indonesia
Standard packing and export terms for this product. Confirm exact figures against your order — they vary slightly by destination and quantity.
What travels with every batch
Specification is agreed before the purchase order, not discovered on arrival. Every shipment of 2-Amino-4-Nitrophenol leaves with a documented, checkable paper trail.
Certificate of Analysis
Batch-wise assay, colour and key physical constants, issued against the agreed specification so your QC team can check it, not just file it.
Safety Data Sheet
GHS-format SDS in English covering hazard classification, handling, storage, first-aid and spill response for the exact grade shipped.
Technical Data Sheet
Reference physical and chemical properties, recommended storage and typical applications, for internal circulation to your process or R&D teams.
Certificate of Origin
Confirms Indonesian origin for customs clearance and any preferential-duty claim at your destination port.
Dangerous Goods Declaration
UN packing group, classification and shipper's declaration prepared ahead of loading so documentation never holds up customs.
Third-Party Inspection
Independent pre-shipment inspection and re-sampling can be arranged on request, at your cost, for buyers who require it as a matter of policy.
Frequently asked questions
What buyers most often ask our sales desk about this grade.
01What is 2-Amino-4-Nitrophenol used for?+
02How is 2-Amino-4-Nitrophenol produced?+
03What grades does Chelora Chemicals supply?+
04Is 2-Amino-4-Nitrophenol hazardous?+
05Why does the exact substitution pattern matter so much for this compound?+
06What packing options are available?+
07How long does delivery take?+
08Can I get a sample before placing a bulk order?+
09Do you supply related aminophenol intermediates as well?+
10What is the minimum order quantity?+
Need 2-Amino-4-Nitrophenol on spec, on time?
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