2,5-Dichloro Phenol
A dichlorinated phenol intermediate supplied by Chelora Chemicals — a versatile chlorophenol building block for dye, pharmaceutical and fine-chemical synthesis — exported from Indonesia with full batch documentation on every shipment.
What 2,5-Dichloro Phenol is, and why buyers source it
A working overview of the compound's chemistry, how its phenolic hydroxyl and two chlorines each offer their own reaction chemistry, and the grades Chelora Chemicals keeps in regular supply.
2,5-Dichloro Phenol is a benzene ring carrying a hydroxyl group at position 1 and chlorine atoms at positions 2 and 5. Like other chlorophenols, it combines the acidic, nucleophilic phenolic oxygen (useful for etherification and esterification) with two ring chlorines that are not strongly activated for nucleophilic displacement by the hydroxyl alone, but which do direct any further electrophilic substitution on the ring and contribute to the molecule's characteristic lipophilicity and antimicrobial-adjacent chlorophenol chemistry.
At room temperature it is a white to light yellow crystalline solid with the characteristic sharp, medicinal odour typical of chlorinated phenols. It is only slightly soluble in water but dissolves readily in common organic solvents, and like other chlorophenols is handled as a toxic and corrosive material under full MSDS guidance.
Where it fits in the synthesis chain
The phenolic hydroxyl is readily converted to ethers and esters, making this compound a useful building block wherever a dichlorophenoxy or dichlorophenyl ester fragment is required in dye, agrochemical or pharmaceutical intermediate chemistry. It is also used directly as a fine-chemical reference compound and as a starting material in broader chlorophenol derivative synthesis.
Grades we supply
Chelora Chemicals offers 2,5-Dichloro Phenol in technical grade (≈97% assay) for standard industrial synthesis, and high-purity grade (99%+) for applications sensitive to colour or isomeric carryover. Both grades are supplied with a batch-wise certificate of analysis.
How 2,5-Dichloro Phenol is made
An overview of the production route for orientation purposes. Our manufacturing partners' own process parameters and in-process controls are proprietary and are not disclosed beyond what is needed to interpret the certificate of analysis.
2,5-Dichloro Phenol is manufactured by the controlled chlorination of phenol with chlorine gas or a chlorinating agent under catalysed conditions, or by hydrolysis of the corresponding dichlorobenzene under alkaline, high-temperature conditions. Phenol's hydroxyl group is itself an activating, ortho/para-directing substituent, so achieving the specific 2,5-substitution pattern (rather than the more commonly favoured 2,4- or 2,6-patterns) requires careful control of chlorination stoichiometry, temperature and catalyst to steer the reaction toward this particular isomer.
After chlorination, the crude product is separated from unreacted phenol and other chlorophenol isomers, washed, and crystallised to the required purity and colour before packing.
Why isomer control matters here
Because phenol chlorination can give a range of mono-, di- and trichlorophenol isomers depending on conditions, the purification train for 2,5-dichlorophenol specifically has to separate it cleanly from its close chlorophenol relatives — buyers with isomer-sensitive downstream chemistry should confirm the isomeric purity specification against their process needs before ordering.
Industries and processes that use it
2,5-Dichloro Phenol is consumed mainly as a building block for dichlorophenoxy and dichlorophenyl ester intermediates across dye, agrochemical and pharmaceutical synthesis. The fields below cover the uses we see through our export desk.
Dye & Pigment Intermediate Chemistry
The phenolic hydroxyl is etherified or esterified to build dichlorophenoxy and dichlorophenyl ester fragments used in dye and pigment intermediate synthesis.
Agrochemical Intermediate Chemistry
Used as a building block in agrochemical synthesis routes that call for a dichlorophenoxy or dichlorophenyl ester fragment.
Pharmaceutical Intermediate Chemistry
Used in pharmaceutical-intermediate synthesis requiring a dichlorophenol building block.
Fine-Chemical Reference & Specialty Synthesis
Used as a well-characterised chlorophenol reference compound and specialty synthesis building block.
How the molecule is typically carried forward
The phenolic hydroxyl is the principal reactive handle, with the two ring chlorines generally carried through unchanged into the finished intermediate. Reaction classes below cover the main ways this material is converted downstream.
Etherification (Williamson-Type)
Reaction with an alkyl or aryl halide under basic conditions displaces the phenolic hydroxyl's proton to form the corresponding ether, a common route to dichlorophenoxy fragments.
Esterification
Reaction with an acyl chloride or anhydride gives the corresponding dichlorophenyl ester, used in further dye and agrochemical intermediate synthesis.
Electrophilic Aromatic Substitution
Further electrophilic substitution on the ring, directed by the hydroxyl and the existing chlorines, can introduce additional substituents for more complex target molecules.
Salt Formation
The acidic phenolic hydroxyl forms well-characterised salts with bases, used in some purification and formulation steps downstream.
2,5-Dichloro Phenol in context
Buyers sourcing this chlorophenol are often working across dye, agrochemical or pharmaceutical intermediate chemistry alongside our other specialty building blocks. A quick reference to related intermediates in our range.
| Product | CAS Number | Category | Notes |
|---|---|---|---|
| 2,5-Dichloro Phenol | 583-78-8 | Dichlorophenol | The product on this page — a versatile phenolic building block. |
| Para Nitrophenol | 100-02-7 | Nitrophenol | A related phenolic intermediate elsewhere in our range — see its product page. |
| Anisole | 100-66-3 | Aromatic ether | The methylated analogue of phenol's reactive oxygen chemistry — see its product page. |
| 2-Hydrazino-4-Methylbenzothiazole | 20174-68-9 | Heterocyclic hydrazine | A related specialty intermediate elsewhere in our range — see its product page. |
Exact physical constants and purity specifications are confirmed per batch on the certificate of analysis — treat the notes above as a sourcing guide, not a specification sheet, for products other than 2,5-Dichloro Phenol.
Safety classification at a glance
Based on GHS classification as commonly listed for this substance. This is a summary for orientation only — always work from the current safety data sheet supplied with your specific batch.
Harmful if swallowed.
Toxic in contact with skin.
Causes severe skin burns and eye damage.
Toxic to aquatic life with long-lasting effects.
As with other chlorophenols, direct contact can cause chemical burns; treat spills and splashes as a corrosive-material incident.
Impervious gloves, chemical splash goggles or a face shield, and suitable respiratory protection are the baseline for routine handling.
Treat as persistent and toxic in the aquatic environment; avoid any release to drains or waterways.
Danger — GHS05 corrosive and GHS06 acute toxicity pictograms apply.
This compound is toxic in contact with skin and causes severe skin burns and eye damage, and is toxic to aquatic life with long-lasting effects; impervious gloves, chemical splash goggles or a face shield, and suitable respiratory protection are the baseline for routine handling, with any skin or eye contact treated as a corrosive-exposure incident requiring immediate first aid. Full first-aid, storage, spill and PPE guidance is in the MSDS issued with every shipment, and should be read in full before this material is handled.
Keeping it on spec between delivery and use
General storage guidance for this grade. Site-specific storage rules, segregation requirements and re-test intervals should follow your own EHS procedures and the MSDS issued with your batch.
Store in a cool, dry, well-ventilated area away from direct sunlight and ignition sources, in tightly closed original packaging, segregated from strong oxidizing agents and strong bases. Avoid generating or accumulating dust during handling. If a batch is held past its retest date, re-check assay, melting point and colour before use.
How it ships from Indonesia
Standard packing and export terms for this product. Confirm exact figures against your order — they vary slightly by destination and quantity.
What travels with every batch
Specification is agreed before the purchase order, not discovered on arrival. Every shipment of 2,5-Dichloro Phenol leaves with a documented, checkable paper trail.
Certificate of Analysis
Batch-wise assay, melting point range, isomer content and colour, issued against the agreed specification so your QC team can check it, not just file it.
Safety Data Sheet
GHS-format SDS in English covering hazard classification, handling, storage, first-aid and spill response for the exact grade shipped.
Technical Data Sheet
Reference physical and chemical properties, recommended storage and typical applications, for internal circulation to your process or R&D teams.
Certificate of Origin
Confirms Indonesian origin for customs clearance and any preferential-duty claim at your destination port.
Dangerous Goods Declaration
UN packing group, classification and shipper's declaration prepared ahead of loading so documentation never holds up customs.
Third-Party Inspection
Independent pre-shipment inspection and re-sampling can be arranged on request, at your cost, for buyers who require it as a matter of policy.
Frequently asked questions
What buyers most often ask our sales desk about this grade.
01What is 2,5-Dichloro Phenol used for?+
02What is the CAS number of 2,5-Dichloro Phenol?+
03How is 2,5-Dichloro Phenol made?+
04What purity grades does Chelora Chemicals supply?+
05Is 2,5-Dichloro Phenol hazardous?+
06Why is the phenolic hydroxyl the main reactive site, rather than the chlorines?+
07What packing options are available?+
08How long does delivery take?+
09Can I get a sample before placing a bulk order?+
10Do you supply other phenolic or chlorophenol intermediates?+
Need 2,5-Dichloro Phenol on spec, on time?
Send us your required purity, quantity, packing preference and destination port. Our desk quotes most enquiries within one working day.